Department of Dermatology, Venereology and Leprosy, JSS Medical College, JSS University, Mysore, Karnataka, India.
Int J Dermatol. 2010 Dec;49(12):1351-61. doi: 10.1111/j.1365-4632.2010.04570.x.
Psoriasis is a common skin disorder; knowledge of the factors that may induce, trigger, or exacerbate the disease is of primary importance in clinical practice. Drug intake is a major concern in this respect, as new drugs are constantly being added to the list of factors that may influence the course of this disease. Drug ingestion may result in exacerbation of pre-existing psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in patients with psoriasis, or in precipitation of the disease in persons without family history of psoriasis or in predisposed individuals. In view of their relationship to drug-provoked psoriasis, therapeutic agents may be classified as drugs with strong evidence for a causal relationship to psoriasis, drugs about which there are considerable but insufficient data to support the induction or aggravation of the disease, and drugs that are occasionally reported to be associated with aggravation or induction. This review focuses on the most common causative agents for drug-induced, drug-triggered, or drug-aggravated psoriasis, such as β-blockers, lithium, synthetic antimalarial drugs, nonsteroidal anti-inflammatory agents, and tetracyclines, and the mechanisms of action of these drugs in the pathogenesis of psoriasis.
银屑病是一种常见的皮肤疾病；了解可能诱发、触发或加重疾病的因素在临床实践中至关重要。在这方面，药物摄入是一个主要关注点，因为新的药物不断被添加到可能影响这种疾病进程的因素列表中。药物摄入可能导致已有的银屑病恶化，在银屑病患者的无临床受累皮肤上诱导出银屑病损害，或在无银屑病家族史或易感个体中引发疾病。鉴于它们与药物诱发的银屑病的关系，治疗药物可分为与银屑病有明确因果关系的药物、有大量但不足以支持疾病诱导或加重的数据的药物，以及偶尔有报道与加重或诱导有关的药物。这篇综述重点介绍了最常见的导致药物诱导、药物触发或药物加重银屑病的原因，如β受体阻滞剂、锂、合成抗疟药物、非甾体抗炎药和四环素，以及这些药物在银屑病发病机制中的作用机制。
