Rongioletti Franco, Fiorucci Cristina, Parodi Aurora
Section of Dermatology, DISEM, University of Genoa, 16132, Genova, Italy.
J Rheumatol Suppl. 2009 Aug;83:59-61. doi: 10.3899/jrheum.090227.
Drug ingestion may result in exacerbation of preexisting psoriasis, induction of psoriatic lesions on clinically uninvolved skin in patients with psoriasis, or precipitation of the disease. In view of their relationship to psoriasis, therapeutic agents may be classified as follows: (1) drugs with strong evidence for a causal relationship to psoriasis including lithium, beta blockers, and synthetic antimalarial drugs; (2) drugs with considerable number of studies but insufficient data to support induction or aggravation of the disease; (3) drugs occasionally reported to be associated with aggravation or induction. While focusing on the most common causative agents for drug induced/aggravated psoriasis, we discuss the controversies about the relationship between drugs and psoriasis and report our own experience at the Section of Dermatology, University of Genoa.
药物摄入可能会导致原有银屑病病情加重，在银屑病患者临床未受累的皮肤上诱发银屑病皮损，或引发该疾病。鉴于它们与银屑病的关系，治疗药物可分类如下：(1) 有充分证据表明与银屑病存在因果关系的药物，包括锂盐、β受体阻滞剂和合成抗疟药；(2) 有大量研究但数据不足以支持诱发或加重该疾病的药物；(3) 偶尔有报道称与病情加重或诱发有关的药物。在关注药物性/加重性银屑病最常见的致病因素时，我们在热那亚大学皮肤科讨论了药物与银屑病之间关系的争议，并报告了我们自己的经验。
