钯(0)催化 1,6-二炔-3-基碳酸酯与亲核官能团的环化反应：通过丙二烯中间体高效合成多环苯并[b]芴衍生物。
Palladium(0)-catalyzed cyclization of 1,6-diyn-3-yl carbonates with a nucleophilic functionality: efficient synthesis of polycyclic benzo[b]fluorene derivatives via allene intermediates.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou, PR China.
出版信息
Org Biomol Chem. 2012 May 14;10(18):3696-704. doi: 10.1039/c2ob07148g. Epub 2012 Apr 3.
PMID:22495553
Abstract
We report in this paper an interesting tandem reaction involving sequential palladium(0)-catalyzed decarboxylation of diynylic carbonates, intramolecular nucleophilic cyclization and Schmittel reaction, which provides a facile method for the synthesis of a variety of polycyclic benzo[b]fluorene derivatives from easily accessible starting materials.
摘要
本文报道了一个有趣的串联反应，涉及钯(0)催化的二炔碳酸酯的顺序脱羧、分子内亲核环化和施密特反应，为从易得的起始原料合成各种多环苯并[b]芴衍生物提供了一种简便的方法。
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