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Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline.在一株对替加环素耐药的肠炎沙门氏菌哈达尔血清型临床分离株中发现了 ramR 突变和 Tn1721 相关 tet(A)变体的存在。
Antimicrob Agents Chemother. 2010 Mar;54(3):1319-22. doi: 10.1128/AAC.00993-09. Epub 2009 Dec 22.
2
The tetA gene decreases tigecycline sensitivity of Salmonella enterica isolates.tetA 基因降低肠沙门氏菌分离株对替加环素的敏感性。
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3
ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.肺炎克雷伯菌临床分离株中对替加环素耐药性降低与 ramR 突变有关。
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4
Roles of and (A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.和（A）突变在赋予碳青霉烯类耐药肺炎克雷伯菌临床分离株对替加环素耐药中的作用。
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Efflux Pump Overexpression Contributes to Tigecycline Heteroresistance in serovar Typhimurium.外排泵过表达导致鼠伤寒沙门氏菌血清型对替加环素的异质性耐药。
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In vivo development of tigecycline resistance in Klebsiella pneumoniae owing to deletion of the ramR ribosomal binding site.肺炎克雷伯菌因 ramR 核糖体结合位点缺失导致替加环素耐药的体内发展。
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Molecular characterization of strains of fluoroquinolone-resistant Salmonella enterica serovar Schwarzengrund carrying multidrug resistance isolated from imported foods.氟喹诺酮耐药鼠伤寒沙门氏菌血清型 Schwarzengrund 株的分子特征，这些菌株携带从进口食品中分离出的多重耐药性。
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Genetic characterisation of clinical Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline: Role of the global regulator RamA and its local repressor RamR.临床肺炎克雷伯菌对替加环素低敏性的遗传特征：全局调控子 RamA 及其局部阻遏子 RamR 的作用。
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Tandem amplification of a plasmid-borne tet(A) variant gene confers tigecycline resistance in Escherichia coli.串联扩增质粒携带的 tet(A) 变体基因可使大肠杆菌对替加环素产生耐药性。
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EPS inhibitor treatment of Salmonella impacts evolution without selecting for resistance to biofilm inhibition.用EPS抑制剂治疗沙门氏菌会影响其进化，且不会选择出对生物膜抑制的抗性。
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The tigecycline resistance mechanisms in Gram-negative bacilli.革兰氏阴性杆菌中替加环素的耐药机制。
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Eng Microbiol. 2024 Aug 17;4(3):100165. doi: 10.1016/j.engmic.2024.100165. eCollection 2024 Sep.
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Could traces of fluoroquinolones in food induce ciprofloxacin resistance in and ? An study in with important implications for maximum residue limits in food.食品中的氟喹诺酮类药物残留是否会诱导 和 对环丙沙星产生耐药性？一项在中国进行的 研究具有重要意义，对食品中的最大残留限量有重要影响。
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Tigecycline Sensitivity Reduction in Due to Widely Distributed (A) Variants.由于广泛分布的（A）变体导致替加环素敏感性降低。
Microorganisms. 2023 Dec 18;11(12):3000. doi: 10.3390/microorganisms11123000.
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Efflux Pumps and Different Genetic Contexts of (X4) Contribute to High Tigecycline Resistance in from Pigs.外排泵和（X4）的不同遗传背景导致猪源 对替加环素的高度耐药性。
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Studies on the Transmission of a Tigecycline Resistance-Mediating (A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process.肠杆菌属通过两步重组过程传播替加环素耐药调节（A）基因变异体的研究。
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Extensive Drug-Resistant Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.从家禽和人类中分离出的广泛耐药菌：对环丙沙星和替加环素共同耐药背后的流行情况及分子决定因素
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Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review.替加环素的抗菌活性、临床疗效以及耐药机制和流行病学：叙述性综述。
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本文引用的文献

1
Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City.纽约市地方性肺炎克雷伯菌临床分离株中acrB及调控基因marA、soxS和ramA的表达与抗菌药物耐药性的相关性
J Antimicrob Chemother. 2009 Aug;64(2):278-83. doi: 10.1093/jac/dkp186. Epub 2009 May 20.
2
Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways.环丙沙星通过至少两种不同途径在鼠伤寒沙门氏菌中引发多重耐药性。
J Antimicrob Chemother. 2009 May;63(5):909-16. doi: 10.1093/jac/dkp054. Epub 2009 Mar 6.
3
A review of tigecycline--the first glycylcycline.替加环素——首个甘氨酰环素类药物的综述。
Int J Antimicrob Agents. 2008 Dec;32 Suppl 4:S215-22. doi: 10.1016/S0924-8579(09)70005-6.
4
Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators.肠炎沙门氏菌中与高水平环丙沙星及多药耐药相关的多种调控途径：RamA及其他全局调控因子的作用
Antimicrob Agents Chemother. 2009 Mar;53(3):1080-7. doi: 10.1128/AAC.01005-08. Epub 2008 Dec 22.
5
Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies.替加环素治疗多重耐药肠杆菌科细菌感染：微生物学和临床研究证据的系统评价
J Antimicrob Chemother. 2008 Nov;62(5):895-904. doi: 10.1093/jac/dkn311. Epub 2008 Aug 1.
6
Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae.肺炎克雷伯菌临床分离株中acrAB和ramA表达的实时荧光定量PCR及统计分析
Antimicrob Agents Chemother. 2008 Sep;52(9):3430-2. doi: 10.1128/AAC.00591-08. Epub 2008 Jul 14.
7
ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.参与鼠伤寒沙门氏菌外排介导的多药耐药性的ramR突变。
Antimicrob Agents Chemother. 2008 Jul;52(7):2428-34. doi: 10.1128/AAC.00084-08. Epub 2008 Apr 28.
8
Tigecycline-resistant Enterococcus faecalis strain isolated from a German intensive care unit patient.从一名德国重症监护病房患者身上分离出的耐替加环素粪肠球菌菌株。
J Antimicrob Chemother. 2008 May;61(5):1182-3. doi: 10.1093/jac/dkn065. Epub 2008 Feb 18.
9
AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii.AdeIJK，一种在鲍曼不动杆菌中排出多种抗生素的耐药-结瘤-细胞分裂泵。
Antimicrob Agents Chemother. 2008 Feb;52(2):557-62. doi: 10.1128/AAC.00732-07. Epub 2007 Dec 17.
10
MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.MarA介导的AcrAB外排泵过表达导致大肠杆菌对替加环素的敏感性降低。
J Antimicrob Chemother. 2008 Jan;61(1):46-53. doi: 10.1093/jac/dkm397. Epub 2007 Oct 29.

在一株对替加环素耐药的肠炎沙门氏菌哈达尔血清型临床分离株中发现了 ramR 突变和 Tn1721 相关 tet(A)变体的存在。

Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline.

机构信息

Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

出版信息

Antimicrob Agents Chemother. 2010 Mar;54(3):1319-22. doi: 10.1128/AAC.00993-09. Epub 2009 Dec 22.

DOI:10.1128/AAC.00993-09
PMID:20028818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2826014/
Abstract

A Salmonella enterica serovar Hadar strain resistant to tigecycline (MIC, 16 microg/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wild-type ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate implicates ramR in resistance to tigecycline.

摘要

一株对替加环素（MIC，16μg/ml）耐药的肠炎沙门氏菌哈达尔（Salmonella enterica serovar Hadar）菌株被分离出来。分子特征分析显示存在一个与 Tn1721 相关的可移动质粒 tet(A)变体，该变体介导替加环素 MIC 升高，当转移到大肠杆菌时会出现这种情况。此外，还检测到 ramR 中的截断突变。用野生型 ramR 转化，但不用突变型 ramR 转化，会降低替加环素的 MIC。对这种沙门氏菌分离株的特征分析表明，ramR 与对替加环素的耐药性有关。