Miller B L, Read S, Tang C, Jenden D
Department of Neurology, Harbor-UCLA Medical Center, Torrance 90509.
Neurobiol Aging. 1991 Jan-Feb;12(1):61-4. doi: 10.1016/0197-4580(91)90040-q.
The concentrations of red blood cell choline, glycerophosphocholine, phosphocholine and lipid-bound choline were measured in patients with Alzheimer disease (AD) and in normal elderly controls. Red blood cell choline in the Alzheimer group (41.4 +/- 9.2 nmol/ml) was significantly higher (p less than 0.023) than in the elderly controls (18.7 +/- 2.3 nmol/ml). Red blood cell lipid-bound choline (1387 +/- 58 nmol/ml) in the AD group was significantly lower (p less than 0.0022) than in the age-matched controls (1667 +/- 65), while there were no significant differences in glycerophosphocholine or phosphocholine. Plasma choline and lipid-bound choline did not differ significantly between the groups. The mechanisms for these changes still need further study, although the finding of decreased lipid-bound choline supports the concept of altered phospholipid metabolism in patients with AD.
对阿尔茨海默病（AD）患者和正常老年对照者的红细胞胆碱、甘油磷酸胆碱、磷酸胆碱和脂质结合胆碱浓度进行了测量。阿尔茨海默病组的红细胞胆碱（41.4±9.2纳摩尔/毫升）显著高于老年对照组（18.7±2.3纳摩尔/毫升）（p<0.023）。AD组的红细胞脂质结合胆碱（1387±58纳摩尔/毫升）显著低于年龄匹配的对照组（1667±65）（p<0.0022），而甘油磷酸胆碱或磷酸胆碱无显著差异。两组间血浆胆碱和脂质结合胆碱无显著差异。尽管脂质结合胆碱降低的发现支持了AD患者磷脂代谢改变的概念，但这些变化的机制仍需进一步研究。
