钯催化苯并咪唑氯与 1,6-烯炔的 Sonogashira 偶联反应及环化合成喹啉衍生物的意外级联反应。
Unexpected domino reaction via Pd-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and cyclization to synthesize quinoline derivatives.
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
出版信息
J Org Chem. 2010 Feb 19;75(4):1305-8. doi: 10.1021/jo9026116.
PMID:20088585
Abstract
A domino reaction via palladium-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and then cyclization to form quinoline derivatives has been developed. The reaction conditions and the scope of the process are examined, and a plausible mechanism is proposed. The procedure is simple, rapid, and general, and the substrates are readily available.
摘要
发展了一种通过钯催化苯并咪唑氯与 1,6-烯炔的 Sonogashira 偶联反应和随后的环化反应形成喹啉衍生物的级联反应。考察了反应条件和过程的范围，并提出了合理的机理。该方法简单、快速、通用，且底物易得。
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