欧洲犬体内的重组犬冠状病毒。
Recombinant canine coronaviruses in dogs, Europe.
机构信息
Department of Veterinary Public Health, Strada per Casamassima km 3, 70010 Valenzano, Bari, Italy.
出版信息
Emerg Infect Dis. 2010 Jan;16(1):41-7. doi: 10.3201/eid1601.090726.
Coronaviruses of potential recombinant origin with porcine transmissible gastroenteritis virus (TGEV), referred to as a new subtype (IIb) of canine coronavirus (CCoV), were recently identified in dogs in Europe. To assess the distribution of the TGEV-like CCoV subtype, during 2001-2008 we tested fecal samples from dogs with gastroenteritis. Of 1,172 samples, 493 (42.06%) were positive for CCoV. CCoV-II was found in 218 samples, and CCoV-I and CCoV-II genotypes were found in 182. Approximately 20% of the samples with CCoV-II had the TGEV-like subtype; detection rates varied according to geographic origin. The highest and lowest rates of prevalence for CCoV-II infection were found in samples from Hungary and Greece (96.87% and 3.45%, respectively). Sequence and phylogenetic analyses showed that the CCoV-IIb strains were related to prototype TGEV-like strains in the 5' and the 3' ends of the spike protein gene.
最近在欧洲的狗中发现了具有猪传染性胃肠炎病毒（TGEV）的潜在重组起源的冠状病毒，称为犬冠状病毒（CCoV）的新亚型（IIb）。为了评估类似于 TGEV 的 CCoV 亚型的分布，我们在 2001-2008 年期间测试了患有胃肠炎的狗的粪便样本。在 1172 个样本中，493 个（42.06％）对 CCoV 呈阳性。发现了 218 个 CCoV-II，182 个 CCoV-I 和 CCoV-II 基因型。大约 20％的 CCoV-II 样本具有类似于 TGEV 的亚型；检测率根据地理位置而有所不同。在匈牙利和希腊的样本中，CCoV-II 感染的流行率最高和最低，分别为 96.87％和 3.45％。序列和系统发育分析表明，CCoV-IIb 株与刺突蛋白基因 5'和 3'末端的原型 TGEV 样株有关。
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