Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada.
Emerg Infect Dis. 2010 Jan;16(1):48-54. doi: 10.3201/eid1601.090729.
The Canadian Integrated Program for Antimicrobial Resistance Surveillance describes a strong correlation (r = 0.9, p<0.0001) between ceftiofur-resistant Salmonella enterica serovar Heidelberg isolated from retail chicken and incidence of ceftiofur-resistant Salmonella serovar Heidelberg infections in humans across Canada. In Quebec, changes of ceftiofur resistance in chicken Salmonella Heidelberg and Escherichia coli isolates appear related to changing levels of ceftiofur use in hatcheries during the study period, from highest to lowest levels before and after a voluntary withdrawal, to increasing levels after reintroduction of use (62% to 7% to 20%, and 34% to 6% to 19%, respectively). These events provide evidence that ceftiofur use in chickens results in extended-spectrum cephalosporin resistance in bacteria from chicken and humans. To ensure the continued effectiveness of extended-spectrum cephalosporins for treating serious infections in humans, multidisciplinary efforts are needed to scrutinize and, where appropriate, limit use of ceftiofur in chicken production in Canada.
加拿大抗菌药物耐药性监测综合计划描述了从零售鸡肉中分离出的对头孢噻呋耐药的肠炎沙门氏菌血清型海德堡与加拿大各地人类感染对头孢噻呋耐药的肠炎沙门氏菌血清型海德堡之间存在很强的相关性（r = 0.9，p<0.0001）。在魁北克，鸡源肠炎沙门氏菌血清型海德堡和大肠埃希菌分离株对头孢噻呋的耐药性变化似乎与研究期间孵化场中头孢噻呋使用水平的变化有关，自愿撤回前后使用水平从最高到最低，重新引入使用后水平增加（分别为 62%至 7%至 20%，和 34%至 6%至 19%）。这些事件提供了证据表明，鸡中头孢噻呋的使用导致了来自鸡和人类的细菌对扩展谱头孢菌素的耐药性。为确保扩展谱头孢菌素继续有效治疗人类的严重感染，需要多学科努力审查并在适当情况下限制加拿大鸡生产中头孢噻呋的使用。
