成人甲型流感相关性急性脑病。
Acute encephalopathy associated with influenza A infection in adults.
机构信息
Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 9/F Clinical Sciences Building, Department of Medicine and Therapeutics, Shatin, Hong Kong, People's Republic of China.
出版信息
Emerg Infect Dis. 2010 Jan;16(1):139-42. doi: 10.3201/eid1601.090007.
Abstract
We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.
摘要
我们报告了 3 例与甲型流感感染相关的急性脑病。我们检测到高浓度的脑脊液 (CSF) 和血浆 CXCL8/IL-8 和 CCL2/MCP-1（CSF/血浆比值≥3），以及白细胞介素-6、CXCL10/IP-10，但没有病毒神经入侵的证据。患者均无后遗症恢复。细胞因子过度激活反应可能在发病机制中起作用。
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