Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Placenta. 2010 Feb;31(2):113-20. doi: 10.1016/j.placenta.2009.11.012. Epub 2009 Dec 23.
Chorioamnionitis, inflammation of the amniochorionic membrane (fetal membranes) is a very common disease but a complex syndrome associated with pregnancy. It presents a clinical impasse due to lack of knowledge of specific etiologies associated with this condition making confident clinical interventions difficult. Recent reports provide insight into genetic, epigenetic, behavioral, psychosocial, molecular and pathophysiological factors that are associated with chorioamnionitis. However, a coordinated approach in understanding causality and lack of early indicators (clinical and biomarkers) has hampered gaining knowledge about the disease status preventing proper intervention. Several reviews have provided in-depth analysis of the histologic and clinical evidence associated with chorioamnionitis. In this review, we provide a novel perspective on chorioamnionitis based on recent evidences from scientific literature on inflammation, apoptosis and genetics.
绒毛膜羊膜炎，即羊膜绒毛膜（胎儿膜）的炎症，是一种非常常见的疾病，但也是一种与妊娠相关的复杂综合征。由于缺乏与这种情况相关的特定病因的知识，导致临床干预措施缺乏信心，这使其成为一个临床难题。最近的报告提供了一些见解，涉及与绒毛膜羊膜炎相关的遗传、表观遗传、行为、社会心理、分子和病理生理学因素。然而，在理解因果关系和缺乏早期指标（临床和生物标志物）方面缺乏协调一致的方法，阻碍了对疾病状态的了解，从而无法进行适当的干预。有几项综述对与绒毛膜羊膜炎相关的组织学和临床证据进行了深入分析。在这篇综述中，我们根据炎症、细胞凋亡和遗传学方面的科学文献中的最新证据，提供了一个关于绒毛膜羊膜炎的新视角。
