Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht Univeristy, P.O. Box 80178, Utrecht, The Netherlands.
Eur Respir J. 2010 Jul;36(1):57-64. doi: 10.1183/09031936.00154509. Epub 2009 Dec 23.
Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset <or=4 yrs) were higher in carriers of risk genotypes (OR 3.42-6.36) than in noncarriers (OR 1.84-2.44; p-value for interaction 0.02-0.04 for five SNPs). Risk genotypes also increased the association between infection and childhood asthma that remits in adulthood (OR 4.84-7.16 in carriers and 1.74-2.25 in noncarriers; p-value for interaction 0.008-0.05 for 10 SNPs). In children with 17q21 risk genotypes and early-life environmental tobacco smoke (ETS) exposure, associations between infection and asthma were further enhanced. 17q21 genetic variants and early ETS exposure enhance the association between early respiratory infections and early-onset asthma and childhood asthma that remits in adulthood.
单核苷酸多态性（SNPs）在染色体 17q21 上增加了早发性哮喘的风险。目的是研究 17q21 SNPs 是否会改变早期呼吸道感染与哮喘之间的关联。关联分析在来自于哮喘遗传与环境研究（EGEA）的 499 名儿童（268 名哮喘患者，中位年龄 11 岁）中进行。使用 12 年的随访数据评估青年期持续性或缓解性哮喘。回顾性评估 2 岁前的呼吸道感染。在研究的 12 个 17q21 SNPs 中，感染与早发性哮喘（发病年龄≤4 岁）之间关联的比值比（OR）在风险基因型携带者（OR 3.42-6.36）中高于非携带者（OR 1.84-2.44；五个 SNPs 的交互作用 p 值为 0.02-0.04）。风险基因型还增加了感染与成年期缓解的儿童哮喘之间的关联（携带者中 OR 4.84-7.16，非携带者中 OR 1.74-2.25；十个 SNPs 的交互作用 p 值为 0.008-0.05）。在携带 17q21 风险基因型和生命早期环境烟草烟雾（ETS）暴露的儿童中，感染与哮喘之间的关联进一步增强。17q21 遗传变异和早期 ETS 暴露增强了早期呼吸道感染与早发性哮喘和成年期缓解的儿童哮喘之间的关联。
