Servicio de Análisis Clínicos, Hospital Clínico San Carlos, 28040, Madrid, España.
Anticancer Res. 2009 Nov;29(11):4839-43.
The aim of this study was the detection of circulating tumor cells (CTC) in three tumor types of epithelial origin.
Four hundred and thirty-eight patients with breast cancer (56.2% localized and 43.8% metastatic), 195 with colorectal tumors (84.1% localized and 15.9% metastatic) and 50 with prostate cancer (52% localized and 48% metastatic) took part in this study. CTC quantification was performed using the CellSpotter Analyzer (Veridex LLC).
31.5% of patients with cancer had > or =2 CTCs/7.5 mL but none of the healthy volunteers were above this level (p<0.001). Among patients with metastatic disease, 62.3% of them had > or =2 CTCs/7.5 mL but only 14.0% of those with localized disease were above this level (p<0.001). The presence of CTCs were correlated to stage in the three studied tumor types and no differences in the number of cells were found between them.
The presence of more than 2 CTCs/7.5 ml is a frequent event in metastatic cases. In particular, patients with localized disease who have more than 2 CTCs/7.5 ml should be carefully studied to determine the possible prognostic and predictive value of this finding.
本研究旨在检测三种上皮来源肿瘤的循环肿瘤细胞（CTC）。
438 例乳腺癌患者（56.2%局限性和 43.8%转移性）、195 例结直肠癌患者（84.1%局限性和 15.9%转移性）和 50 例前列腺癌患者（52%局限性和 48%转移性）参与了本研究。CTC 定量采用 CellSpotter 分析仪（Veridex LLC）进行。
31.5%的癌症患者有>或=2 CTCs/7.5 mL，但无健康志愿者超过此水平（p<0.001）。在转移性疾病患者中，62.3%的患者有>或=2 CTCs/7.5 mL，但局限性疾病患者中只有 14.0%超过此水平（p<0.001）。CTC 的存在与三种研究肿瘤类型的分期相关，且它们之间的细胞数量无差异。
在转移性病例中，超过 2 CTCs/7.5 ml 的存在是常见事件。特别是，局限性疾病患者中超过 2 CTCs/7.5 ml 的患者应仔细研究，以确定这一发现的可能预后和预测价值。
