Bai Shiyan, Lin Shujin, Lin Ting, Wang Qiaowen, Cheng Cui, Lin Junru, Zhang Ying, Jiang Xiwen, Han Xiao
College of Biological Science and Engineering, Fuzhou University, Fuzhou, China.
Industrial Management Engineering, National University of Singapore, Singapore, Singapore.
Front Oncol. 2023 Jun 16;13:1137519. doi: 10.3389/fonc.2023.1137519. eCollection 2023.
Using meta-analysis, we evaluate circulating tumor cells(CTCs) as a potential diagnostic tool for breast cancer.
A document search was conducted using publicly available databases up to May 2021. Specific inclusion and exclusion criteria were formulated and summarize relevant data through literature types, research types, case populations, samples, etc. Subgroup analysis of documents based on regions, enrichment methods, and detection methods. The included research projects were evaluated using DeeKs' bias, and evaluation indicators such as specificity (SPE), sensitivity (SEN), diagnosis odds ratio (DOR) were used as evaluation indicators.
16 studies on the use of circulating tumor cells to diagnose breast cancer were included in our meta-analysis. Overall sensitivity value was 0.50 (95%CI:0.48-0.52), specificity value was 0.93 (95%CI:0.92- 0.95), DOR value was 33.41 (95%CI:12.47-89.51), and AUC value was 0.8129.
In meta-regressions and subgroup analysis, potential heterogeneity factors were analyzed, but the source of heterogeneity is still unclear. CTCs, as a novel tumor marker, have a good diagnostic value, but its enrichment and detection methods still need to continue to be developed to improve detection accuracy. Therefore, CTCs can be used as an auxiliary means of early detection, which is helpful to the diagnosis and screening of breast cancer.
通过荟萃分析，评估循环肿瘤细胞（CTCs）作为乳腺癌潜在诊断工具的价值。
利用公开数据库检索截至2021年5月的文献。制定了具体的纳入和排除标准，并通过文献类型、研究类型、病例人群、样本等对相关数据进行总结。基于地区、富集方法和检测方法对文献进行亚组分析。采用DeeKs偏倚对纳入的研究项目进行评估，并将特异性（SPE）、敏感性（SEN）、诊断比值比（DOR）等评估指标作为评价指标。
我们的荟萃分析纳入了16项关于使用循环肿瘤细胞诊断乳腺癌的研究。总体敏感性值为0.50（95%CI：0.48 - 0.52），特异性值为0.93（95%CI：0.92 - 0.95），DOR值为33.41（95%CI：12.47 - 89.51），AUC值为0.8129。
在荟萃回归和亚组分析中，对潜在的异质性因素进行了分析，但异质性来源仍不清楚。CTCs作为一种新型肿瘤标志物，具有良好的诊断价值，但其富集和检测方法仍需不断改进以提高检测准确性。因此，CTCs可作为早期检测的辅助手段，有助于乳腺癌的诊断和筛查。
