Bannatyne R M, Harnett N M, Cheung R
Can J Microbiol. 1977 Nov;23(11):1526-8. doi: 10.1139/m77-226.
The mouse model of intraperitoneal meningococcal sepsis was used to evaluate the antiendotoxic activity of polymyxin B sulfate independent of its antibiotic effects. Administered either before or after the infective challenge therapeutic doses of polymyxin B sulfate produced small but significant increases in survival over unprotected animals. These results also suggest that endotoxin contributes to the outcome in this variety of Gram-negative infection.
