硫酸多粘菌素B对小鼠实验性肠道细菌感染的保护作用。
Protective effect of polymyxin B sulfate in experimental enterobacterial infection in mice.
作者信息
Bannatyne R M, Cheung R
出版信息
Can J Microbiol. 1979 Sep;25(9):995-8. doi: 10.1139/m79-153.
DOI:10.1139/m79-153
PMID:232006
Abstract
The mouse model of intraperitoneal enterobacterial sepsis was used to evaluate the anti-endotoxic effect of polymyxin B sulfate. Single or multiple therapeutic doses of polymyxin, administered either before or after lethal challenge with Serratia marcescens, produced statistically and clinically significant protective effects.
摘要
采用腹腔内肠杆菌败血症小鼠模型评估硫酸多粘菌素B的抗内毒素作用。在用粘质沙雷氏菌进行致死性攻击之前或之后给予单次或多次治疗剂量的多粘菌素，产生了具有统计学意义和临床意义的保护作用。
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