Katzenstein A L, Askin F B, Feldman P S
Cancer. 1977 Nov;40(5):2233-42. doi: 10.1002/1097-0142(197711)40:5<2233::aid-cncr2820400533>3.0.co;2-l.
Four cases of uterine müllerian adenosarcoma, a distinctive form of mixed müllerian tumor, were studied by light and electron microscopy. All tumors showed the characteristic histologic pattern of benign neoplastic glands within sarcomatous stroma. Ultrastructurally, both mesenchymal and epithelial cells were seen. The mesenchymal cells showed some features of endometrial stromal cells, including the presence of intracytoplasmic collagen fibers. The epithelial cells formed glands, which resembled benign endometrial glands and were separated from the stroma by a well-defined basal lamina. No transitional cells between the epithelial and mesenchymal cells were seen. The ultrastructural features of these tumors suggest that the sarcomatous portion is of endometrial stromal origin. The glandular portion may arise, along with the stroma, from multipotential stem cells, or the glands may be non-neoplastic entrapped endometrial glands stimulated by the stroma and thus appearing to form an integral part of the tumor.
对4例子宫苗勒管腺肉瘤（一种独特类型的混合性苗勒管肿瘤）进行了光镜和电镜研究。所有肿瘤均呈现出肉瘤性间质内良性肿瘤性腺体的特征性组织学模式。在超微结构上，可见间充质细胞和上皮细胞。间充质细胞表现出一些子宫内膜间质细胞的特征，包括胞质内存在胶原纤维。上皮细胞形成腺体，类似于良性子宫内膜腺体，并通过明确的基膜与间质分隔。未见到上皮细胞和间充质细胞之间的过渡细胞。这些肿瘤的超微结构特征提示肉瘤部分起源于子宫内膜间质。腺性部分可能与间质一起起源于多能干细胞，或者这些腺体可能是受间质刺激的非肿瘤性陷入的子宫内膜腺体，因此似乎构成肿瘤的一个整体部分。
