Bibro M C, LiVolsi V A, Schwartz P E
Am J Clin Pathol. 1979 Jan;71(1):112-7. doi: 10.1093/ajcp/71.1.112.
Müllerian adenosarcoma has been recently described as a distinctive biphasic uterine tumor with benign epithelial and malignant stromal components. The lesion belongs generally to the group of mixed müllerian tumors, but the benignity of the epithelium separates it from the other neoplasms of this type. This entity usually affects postmenopausal patients who follow a protracted course. This paper reports a case fulfilling the original clinical and pathologic description of Clement and Scully and adds ultrastructural observations. Electron microscopic examination confirmed the optical impression of a biphasic neoplasm with benign epithelial and malignant stromal components. The epithelium resembled proliferative endometrium, and the stroma had features of endometrial stromal sarcoma or mixed müllerian tumor. The findings of stromal resemblance to endometrial stromal sarcoma or mixed müllerian tumor and the presence of a variety of müllerian epithelia support the proposed müllerian derivation of this lesion.
苗勒管腺肉瘤最近被描述为一种具有良性上皮和恶性间质成分的独特的双相性子宫肿瘤。该病变一般属于混合性苗勒管肿瘤组，但上皮的良性特征使其与其他此类肿瘤相区分。这种实体通常影响病程迁延的绝经后患者。本文报告了1例符合Clement和Scully最初临床及病理描述的病例，并补充了超微结构观察结果。电子显微镜检查证实了该双相性肿瘤具有良性上皮和恶性间质成分的光学印象。上皮类似于增殖期子宫内膜，间质具有子宫内膜间质肉瘤或混合性苗勒管肿瘤的特征。间质与子宫内膜间质肉瘤或混合性苗勒管肿瘤相似的发现以及多种苗勒管上皮的存在支持了该病变起源于苗勒管的观点。
