Damjanov I, Casey M J, Maenza R M, Kennedy A W
Am J Clin Pathol. 1978 Jul;70(1):96-103. doi: 10.1093/ajcp/70.1.96.
A case of müllerian adenosarcoma arising in the endometrium was studied by light and electron microscopy before and after radiation treatment. The tumor was composed of malignant stroma containing undifferentiated mesenchymal cells admixed with mature fibroblasts and other cell that contained crystalloids. The surface epithelium was lined by epithelial cells with and without cilia, similar to the normal surface epithelium cells of the uterus. High-dose therapeutic irradiation eliminated the undifferentiated mesenchymal cells from the tumor but did not alter the morphology of other epithelial and mesenchymal elements. The immaturity of mesenchymal cells and their radiosensitivity coupled with the ultrasonographic evidence of growth of the tumor point to the probable malignant nature of this neoplasm.
对一例子宫内膜米勒管腺肉瘤放疗前后进行了光镜和电镜研究。肿瘤由恶性间质组成，其中含有未分化间充质细胞，并混有成熟的成纤维细胞和其他含晶体的细胞。表面上皮由有纤毛和无纤毛的上皮细胞构成，类似于子宫正常表面上皮细胞。高剂量治疗性放疗消除了肿瘤中的未分化间充质细胞，但未改变其他上皮和间充质成分的形态。间充质细胞的不成熟及其放射敏感性，再加上肿瘤生长的超声证据，提示该肿瘤可能具有恶性性质。
