Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, Bologna, Italy.
Int J Geriatr Psychiatry. 2010 Oct;25(10):1055-64. doi: 10.1002/gps.2462.
To evaluate the effects of endurance exercise training (EET) on the cognitive status of healthy community-dwelling older adults.
A randomized controlled trial was conducted involving community-dwelling older adults from the town of Pianoro (northern Italy). We randomized 120 healthy subjects aged 65-74 years, both genders, to treatment (N = 60) and control (N = 60) groups. The treatment consisted of 12 months of supervised EET in a community gym, 3 h a week. All participants were assessed both at baseline and after 12 months on an intention-to-treat analysis. Cognitive status was assessed by one single test (Mini Mental State Examination, MMSE). Anthropometric indexes, routine laboratory measurements and C-reactive protein (CRP) were also assessed.
The control group showed a significant decrease in MMSE score (mean difference -1.21, 95% CI -1.83/-0.60, p = 0.0002), which differed significantly (p = 0.02) from the treatment group scores (-0.21, 95% CI -0.79/0.37, p = 0.47). The odds ratio for the treated older adults to have a stable cognitive status after 1 year, as compared to the control group, was 2.74 (95% CI 1.16/6.48) after adjustment for age, gender, educational level and several other possible confounders. Blood pressure, body mass index, waist circumference and serum cholesterol did not differ significantly between the two groups, while CRP decreased only in the treatment group.
A 12-month EET intervention may reduce the progression of age-related cognitive decline in healthy older adults.
评估耐力运动训练（EET）对健康社区居住的老年人认知状态的影响。
一项随机对照试验在意大利北部皮阿诺罗镇的社区居住的老年人中进行。我们将 120 名年龄在 65-74 岁的健康受试者随机分为治疗组（N=60）和对照组（N=60）。治疗组接受 12 个月的社区健身房监督 EET，每周 3 小时。所有参与者均在基线和 12 个月后进行意向治疗分析。认知状态通过单一测试（迷你精神状态检查，MMSE）进行评估。还评估了人体测量指数、常规实验室测量和 C 反应蛋白（CRP）。
对照组的 MMSE 评分显著下降（平均差异-1.21，95%置信区间-1.83/-0.60，p=0.0002），与治疗组评分（-0.21，95%置信区间-0.79/0.37，p=0.47）差异显著。经过年龄、性别、教育水平和其他几个可能的混杂因素调整后，治疗组老年人在 1 年后认知状态稳定的可能性与对照组相比，比值比为 2.74（95%置信区间 1.16/6.48）。两组之间的血压、体重指数、腰围和血清胆固醇无显著差异，而 CRP 仅在治疗组中下降。
12 个月的 EET 干预可能会减缓健康老年人认知能力随年龄增长而下降的速度。
