Izumi Allan
Department of Dermatology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, USA.
Hawaii Med J. 2009 Dec;68(11):277-8.
Ninety percent of varicella infections are seen in children under the age of ten and usually follow a benign clinical course with complete resolution of symptoms in one to three weeks. Herpes zoster an acute vesicular eruption due to the varicella-zoster virus (VZV), occurs mostly in adults. Biologic agents include tumor necrosis factor alpha (TNF-alpha) inhibitors that have significantly impacted the treatment of autoimmune and inflammatory conditions. Therapy with TNF-alpha inhibitors poses a potential risk of serious infections secondary to their immunomodulating properties; however multiple studies have demonstrated acceptable safety and tolerability profiles. A case of documented VZV infection (varicella) in an adult receiving the TNF-alpha inhibitor etanercept is described here.
90%的水痘感染见于10岁以下儿童，通常临床过程良性，症状在1至3周内完全消退。带状疱疹是由水痘-带状疱疹病毒（VZV）引起的急性水疱性皮疹，多见于成年人。生物制剂包括肿瘤坏死因子α（TNF-α）抑制剂，它们对自身免疫性和炎性疾病的治疗产生了重大影响。TNF-α抑制剂治疗因其免疫调节特性而存在严重感染的潜在风险；然而，多项研究已证明其安全性和耐受性良好。本文描述了1例接受TNF-α抑制剂依那西普治疗的成人发生确诊VZV感染（水痘）的病例。
