Mayo Clinic, Rochester, MN, USA.
Med Oncol. 2010 Jun;27 Suppl 1:S14-24. doi: 10.1007/s12032-009-9370-1. Epub 2009 Dec 25.
The past decade has seen incredible progress in the treatment of myeloma as a result of more widespread application of autologous stem cell transplantation and introduction of several new drugs. Hence, the survival of patients with this disease has significantly improved during this period. The treatment approach for patients with myeloma has undergone a paradigm shift as a result of the different choices available for treating the patients with newly diagnosed myeloma. In addition, appreciation of the heterogeneity in the outcome of these patients and the impact of genetics on the prognosis has led to efforts at developing a risk-adapted approach to treatment. This article summarizes the recent advances in the treatment of newly diagnosed myeloma and suggests a treatment algorithm for approaching newly diagnosed myeloma.
过去十年，由于自体干细胞移植的广泛应用和几种新药的引入，骨髓瘤的治疗取得了令人瞩目的进展。因此，在此期间，该病患者的生存率显著提高。由于新诊断骨髓瘤患者的治疗选择不同，骨髓瘤患者的治疗方法发生了范式转变。此外，对这些患者结局的异质性和遗传对预后的影响的认识，促使人们努力开发一种针对治疗的风险适应性方法。本文总结了新诊断骨髓瘤治疗的最新进展，并提出了一种新诊断骨髓瘤的治疗算法。
