Bromley B, Frigoletto F D, Benacerraf B R
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Am J Obstet Gynecol. 1991 Mar;164(3):863-7. doi: 10.1016/0002-9378(91)90530-5.
The neonatal, pathologic outcome and karyotypic abnormalities are reported for 44 fetuses with mild ventriculomegaly diagnosed antenatally. Seventeen of these 44 fetuses (39%) had other ultrasonographic defects, and five (12%) had abnormal karyotypes. Five pregnancies were electively aborted and three other fetuses died in the neonatal period. Twenty-six (72%) of the remaining 36 live-born neonates are developmentally and clinically normal at 3 to 18 months of age. Twenty-one of these 26 had isolated mild ventriculomegaly as the only ultrasonographic finding. The other 10 live-born infants are developmentally impaired, and five of these 10 had mild ventriculomegaly as the only prenatal ultrasonographic abnormality. In conclusion, these data show that fetuses with mild ventriculomegaly have a lower incidence of associated anomalies and a better outcome than fetuses with more severe ventricular dilatation, as reported in the literature. The majority of fetuses with mild ventriculomegaly as an isolated finding and a normal karyotype are developing normally.
报告了44例产前诊断为轻度脑室扩大的胎儿的新生儿情况、病理结果和核型异常。这44例胎儿中有17例（39%）存在其他超声缺陷，5例（12%）核型异常。5例妊娠被选择性终止，另有3例胎儿在新生儿期死亡。其余36例活产新生儿中，26例（72%）在3至18个月时发育和临床正常。这26例中有21例仅有孤立性轻度脑室扩大这一超声表现。其他10例活产婴儿发育受损，其中5例仅有轻度脑室扩大这一产前超声异常表现。总之，这些数据表明，与文献报道的更严重脑室扩张的胎儿相比，轻度脑室扩大的胎儿相关畸形的发生率较低，结局更好。大多数仅有轻度脑室扩大且核型正常的胎儿发育正常。
