Patel M D, Filly A L, Hersh D R, Goldstein R B
Department of Radiology, University of California, San Francisco.
Radiology. 1994 Sep;192(3):759-64. doi: 10.1148/radiology.192.3.7520183.
To assess the outcome of fetuses with isolated mild ventriculomegaly (IMVM).
The clinical course of 44 fetuses with IMVM was investigated. Cognitive and motor development was classified as normal or delayed.
Clinical data were available for 37 subjects. Three (8%) neonates died. Of the 34 living children, follow-up was limited (< 9 months) in six and the clinical course beyond the 1st year of life was established in 28. Twenty-two (79%) of the 28 children are developing normally, whereas six (21%) are developmentally delayed. More than 90% of fetuses with ventricular atrial diameter of 10-11 mm are normal. Seventy-five percent of fetuses with IMVM were male. With exclusion of the six children with limited follow-up, 78% of boys older than 1 year are developmentally normal compared with only 50% of girls.
The majority of living children with prenatally detected IMVM are developmentally normal, especially those with borderline ventriculomegaly. Gender differences in prevalence and outcome deserve further investigation.
评估孤立性轻度脑室扩张（IMVM）胎儿的预后情况。
对44例IMVM胎儿的临床病程进行了调查。认知和运动发育分为正常或延迟。
37例受试者有临床资料。3例（8%）新生儿死亡。在34名存活儿童中，6名随访受限（<9个月），28名确立了1岁以后的临床病程。28名儿童中有22名（79%）发育正常，而6名（21%）发育延迟。脑室心房直径为10 - 11毫米的胎儿中，超过90%是正常的。IMVM胎儿中75%为男性。排除6名随访受限的儿童后，1岁以上男孩发育正常的比例为78%，而女孩仅为50%。
产前检测出IMVM的大多数存活儿童发育正常，尤其是那些临界脑室扩张的儿童。患病率和预后的性别差异值得进一步研究。
