Mahoney M C, Nasca P C, Burnett W S, Melius J M
Division of Occupational Health and Environmental Epidemiology, New York State Department of Health, Albany 12237-0683.
Am J Public Health. 1991 Apr;81(4):475-9. doi: 10.2105/ajph.81.4.475.
Recent animal studies of the potential carcinogenicity of fluoride prompted an examination of bone cancer incidence rates.
Trends in the incidence of primary bone cancers, including the incidence of osteosarcomas were examined among residents of New York State, exclusive of New York City. Average annual osteosarcoma incidence rates in fluoridated and non-fluoridated areas were also compared.
Among persons less than 30 years of age at diagnosis, bone cancer incidence among males demonstrated a significant increase since 1955, while incidence among females has remained unchanged. A significant decrease in bone cancer incidence rates since 1955 was observed among both males and females age 30 years and over at time of diagnosis. Osteosarcoma incidence rates have remained essentially unchanged since 1970, among both younger and older males and females. The average annual age adjusted incidence of osteosarcomas (1976-1987) in areas served by fluoridated water supplies was not found to differ from osteosarcoma incidence rates in non-fluoridated areas.
These data do not support an association between fluoride in drinking water and the occurrence of cancer of the bone.
近期关于氟潜在致癌性的动物研究促使人们对骨癌发病率进行调查。
对纽约州（不包括纽约市）居民中原发性骨癌的发病率趋势，包括骨肉瘤的发病率进行了调查。还比较了氟化地区和非氟化地区的年均骨肉瘤发病率。
在诊断时年龄小于30岁的人群中，自1955年以来男性骨癌发病率显著上升，而女性发病率保持不变。在诊断时年龄30岁及以上的男性和女性中，自1955年以来骨癌发病率均显著下降。自1970年以来，无论年轻还是年长的男性和女性，骨肉瘤发病率基本保持不变。未发现饮用氟化水地区的年均年龄调整后的骨肉瘤发病率（1976 - 1987年）与非氟化地区的骨肉瘤发病率存在差异。
这些数据不支持饮用水中的氟与骨癌发生之间存在关联。
