Freni S C, Gaylor D W
Division of Biometry and Risk Assessment, Food and Drug Administration, Jefferson, Arizona 72079.
Cancer. 1992 Aug 1;70(3):611-8. doi: 10.1002/1097-0142(19920801)70:3<611::aid-cncr2820700312>3.0.co;2-w.
Because osteosarcomas may develop in rats exposed to fluoridated water, water fluoridation might pose a cancer risk to humans.
A time trend analysis of the cumulative risk (CR) of bone cancer for the period 1958-1987 for 40 cancer registry areas showed an increased risk for young males in Canada, Europe, and the United States, and a decreased lifetime risk for either sex in Europe.
This was unrelated to water fluoridation and may have resulted from changes in coding practices. Bone cancer risk was inversely related to the incidence of cancers of unknown origin, suggesting that bone metastases were erroneously coded as primary bone cancer. In 1968-1972, most areas recorded more bone cancer deaths than new cases of the disease.
The mortality/incidence ratio, but not the incidence rate (IR), has dropped sharply since then, which erodes the basis of past inferences relating cancer mortality to fluoridation.
由于暴露于含氟水中的大鼠可能会发生骨肉瘤，因此水的氟化作用可能会给人类带来癌症风险。
对40个癌症登记地区1958 - 1987年期间骨癌累积风险（CR）的时间趋势分析表明，加拿大、欧洲和美国的年轻男性风险增加，而欧洲任何性别的终生风险降低。
这与水的氟化作用无关，可能是编码方式变化所致。骨癌风险与不明来源癌症的发病率呈负相关，这表明骨转移瘤被错误地编码为原发性骨癌。在1968 - 1972年期间，大多数地区记录的骨癌死亡人数多于该疾病的新发病例数。
自那时起，死亡率/发病率比值大幅下降，但发病率（IR）并未下降，这削弱了过去将癌症死亡率与氟化作用相关联的推断基础。
