Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
J Neurosci Methods. 2010 Mar 15;187(1):67-72. doi: 10.1016/j.jneumeth.2009.12.015. Epub 2009 Dec 29.
The present work introduces an electrode microdrive system small enough to be placed into two distinct brain areas in head-fixed mice. To meet the space constraint imposed by the size of mice and the additional presence of a head post, the size and weight of the components were minimized. In the current version, an individual microdrive moves an array of four Reitboeck type electrodes. We report about successful implantation in rats and mice using one or two microdrives. Using two of these devices in individual mice/rats, the recording of parallel single and multi-unit as well as local field potential from prefrontal, motor, somatosensory cortex and hippocampus is demonstrated. The system can be easily constructed with machinery and equipment present in most neurophysiology labs.
本工作介绍了一种电极微驱动器系统，其体积足够小，可以放置在头部固定的小鼠的两个不同脑区。为了满足由小鼠尺寸和附加头柱引起的空间限制，组件的尺寸和重量被最小化。在当前版本中，单个微驱动器移动四个 Reitboeck 型电极的阵列。我们报告了使用一个或两个微驱动器在大鼠和小鼠中成功植入的情况。在单个小鼠/大鼠中使用两个这样的设备，从前额叶、运动、感觉皮层和海马体记录平行的单个和多单位以及局部场电位。该系统可以使用大多数神经生理学实验室中现有的机械和设备轻松构建。
