Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA.
Hum Genomics. 2009 Dec;4(2):136-42. doi: 10.1186/1479-7364-4-2-136.
The website www.aldh.org is a publicly available database for nomenclature and functional and molecular sequence information for members of the aldehyde dehydrogenase (ALDH) gene superfamily for animals, plants, fungi and bacteria. The site has organised gene-specific records. It provides synopses of ALDH gene records, marries trivial terms to correct nomenclature and links global accession identifiers with source data. Server-side alignment software characterises the integrity of each sequence relative to the latest genomic assembly and provides identifier-specific detail reports, including a graphical presentation of the transcript's exon-intron structure, its size, coding sequence, genomic strand and locus. Also included are a summary of substrates, inhibitors and enzyme kinetics. The site provides reference lists and is designed to facilitate data mining by interested investigators.
www.aldh.org 网站是一个可供公众使用的数据库,用于动物、植物、真菌和细菌的醛脱氢酶 (ALDH) 基因超家族成员的命名法以及功能和分子序列信息。该网站组织了基因特异性记录。它提供了 ALDH 基因记录的概要,将琐碎的术语与正确的命名法联系起来,并将全球访问标识符与源数据联系起来。服务器端的对齐软件描述了每个序列相对于最新基因组组装的完整性,并提供了标识符特定的详细报告,包括转录本外显子-内含子结构、其大小、编码序列、基因组链和基因座的图形表示。还包括底物、抑制剂和酶动力学的摘要。该网站提供参考列表,旨在方便有兴趣的研究人员进行数据挖掘。