CSIRO Molecular and Health Technologies, Private Bag 10, Clayton South MDC, VIC 3169, Australia.
Langmuir. 2010 May 4;26(9):6240-9. doi: 10.1021/la904006q.
Lanthanide salts of phytanic acid, an isoprenoid-type amphiphile, have been synthesized and characterized. Elemental analysis and FTIR spectroscopy were used to confirm the formed product and showed that three phytanate anions are complexed with one lanthanide cation. The physicochemical properties of the lanthanide phytanates were investigated using DSC, XRD, SAXS, and cross-polarized optical microscopy. Several of the hydrated salts form a liquid-crystalline hexagonal columnar mesophase at room temperature, and samarium(III) phytanate forms this phase even in the absence of water. Select lanthanide phytanates were dispersed in water, and cryo-TEM images indicate that some structure has been retained in the dispersed phase. NMR relaxivity measurements were conducted on these systems. It has been shown that a particulate dispersion of gadolinium(III) phytanate displays proton relaxivity values comparable to those of a commercial contrast agent for magnetic resonance imaging and a colloidal dispersion of europium(III) phytanate exhibits the characteristics of a fluorescence imaging agent.
植烷酸的镧盐，一种类异戊二烯型两亲分子，已被合成并进行了表征。元素分析和傅里叶变换红外光谱用于确认形成的产物，并表明三个植酸盐阴离子与一个镧离子配位。通过差示扫描量热法、X 射线衍射、小角 X 射线散射和偏光显微镜研究了镧系植酸盐的物理化学性质。几种水合盐在室温下形成六方柱状向列型中间相，即使在没有水的情况下，钐(III)植酸盐也能形成这种相。选择的镧系植酸盐分散在水中，低温透射电子显微镜图像表明分散相中保留了一些结构。对这些系统进行了 NMR 弛豫率测量。结果表明，镧系植酸钆的颗粒分散体显示出与磁共振成像用商业对比剂相当的质子弛豫率值，而镧系植酸铕的胶体分散体表现出荧光成像剂的特性。
