Molecular Imaging Program, National Cancer Institute/NIH, Bldg. 10, Room B3B69, MSC 1088, 10 Center Dr Bethesda, Maryland 20892-1088, USA.
Chem Soc Rev. 2011 Sep;40(9):4626-48. doi: 10.1039/c1cs15077d. Epub 2011 May 23.
In recent years, numerous in vivo molecular imaging probes have been developed. As a consequence, much has been published on the design and synthesis of molecular imaging probes focusing on each modality, each type of material, or each target disease. More recently, second generation molecular imaging probes with unique, multi-functional, or multiplexed characteristics have been designed. This critical review focuses on (i) molecular imaging using combinations of modalities and signals that employ the full range of the electromagnetic spectra, (ii) optimized chemical design of molecular imaging probes for in vivo kinetics based on biology and physiology across a range of physical sizes, (iii) practical examples of second generation molecular imaging probes designed to extract complementary data from targets using multiple modalities, color, and comprehensive signals (277 references).
近年来，已经开发出许多用于体内分子成像的探针。因此，大量关于设计和合成分子成像探针的出版物已经发表，重点关注每种模态、每种类型的材料或每种目标疾病。最近，设计出了具有独特、多功能或多重功能的第二代分子成像探针。这篇综述重点讨论了（i）使用组合模态和信号的分子成像，这些模态和信号利用了整个电磁频谱，（ii）基于生物学和生理学在一系列物理尺寸上对体内动力学进行优化的化学设计，（iii）使用多种模态、颜色和综合信号从目标中提取互补数据的第二代分子成像探针的实际示例（277 个参考文献）。
