前额形态、5-HTTLPR 多态性与情绪刺激的偏向注意。
Prefrontal morphology, 5-HTTLPR polymorphism and biased attention for emotional stimuli.
机构信息
Department of Psychology, University of Texas at Austin, TX 78712, USA.
出版信息
Genes Brain Behav. 2010 Mar 1;9(2):224-33. doi: 10.1111/j.1601-183X.2009.00550.x. Epub 2009 Nov 2.
Abstract
Biased attention for emotional stimuli has been associated with vulnerability to psychopathology. This study examines the neural substrates of biased attention. Twenty-three adult women completed high-resolution structural imaging followed by a standard behavioral measure of biased attention (i.e. spatial cueing task). Participants were also genotyped for the serotonin transporter-linked promoter region (5-HTTLPR) gene. Results indicated that lateral prefrontal cortex (lPFC) morphology was inversely associated with maintained attention for positive and negative stimuli, but only among short 5-HTTLPR allele carriers. No such associations were observed for the medial prefrontal cortex (mPFC) or the amygdala. Results from this study suggest that brain regions involved in cognitive control of emotion are also associated with attentional biases for emotion stimuli among short 5-HTTLPR allele carriers.
摘要
对情绪刺激的偏见性注意与精神病理学的易感性有关。本研究探讨了偏见性注意的神经基础。23 名成年女性完成了高分辨率结构成像，然后进行了标准的偏见性注意行为测量（即空间提示任务）。参与者还接受了 5-羟色胺转运体启动子区域（5-HTTLPR）基因的基因分型。结果表明，外侧前额叶皮层（lPFC）形态与对正性和负性刺激的注意力维持呈负相关，但仅在短 5-HTTLPR 等位基因携带者中观察到这种关联。内侧前额叶皮层（mPFC）或杏仁核则没有观察到这种关联。本研究的结果表明，参与情绪认知控制的大脑区域也与短 5-HTTLPR 等位基因携带者对情绪刺激的注意力偏差有关。
相似文献
1
Prefrontal morphology, 5-HTTLPR polymorphism and biased attention for emotional stimuli.前额形态、5-HTTLPR 多态性与情绪刺激的偏向注意。
Genes Brain Behav. 2010 Mar 1;9(2):224-33. doi: 10.1111/j.1601-183X.2009.00550.x. Epub 2009 Nov 2.
2
Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism.额叶-边缘白质通路与血清素转运体基因启动子区域（5-HTTLPR）多态性的关联。
J Neurosci. 2009 May 13;29(19):6229-33. doi: 10.1523/JNEUROSCI.0896-09.2009.
3
Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli.血清素转运体基因启动子区域（5-HTTLPR）多态性与对情绪刺激的偏向性注意的关联。
J Abnorm Psychol. 2009 Aug;118(3):670-81. doi: 10.1037/a0016198.
4
Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information.5-羟色胺转运体基因启动子区（5-HTTLPR）多态性与情绪信息注视偏向的关系。
J Abnorm Psychol. 2011 Feb;120(1):187-97. doi: 10.1037/a0022125.
5
Relationship of the serotonin transporter gene promoter polymorphism (5-HTTLPR) genotype and serotonin transporter binding to neural processing of negative emotional stimuli.血清素转运体基因启动子多态性（5-HTTLPR）基因型与血清素转运体结合与负面情绪刺激神经加工的关系。
J Affect Disord. 2016 Jan 15;190:494-498. doi: 10.1016/j.jad.2015.10.047. Epub 2015 Nov 4.
6
The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.5-羟色胺转运体基因（5-HTTLPR）多态性影响健康成年人视觉-边缘系统的基于网络的功能连接。
Neuropsychopharmacology. 2018 Jan;43(2):406-414. doi: 10.1038/npp.2017.121. Epub 2017 Jun 7.
7
Volition diminishes genetically mediated amygdala hyperreactivity.意志降低了基因介导的杏仁核过度反应。
Neuroimage. 2010 Nov 15;53(3):943-51. doi: 10.1016/j.neuroimage.2009.11.078. Epub 2009 Dec 5.
8
Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients.血清素转运体基因变异与精神科住院患者对情绪性词汇刺激的偏向性注意
J Abnorm Psychol. 2007 Feb;116(1):208-12. doi: 10.1037/0021-843X.116.1.208.
9
Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity.认知评价和生活压力调节 5-HTTLPR 多态性对杏仁核反应性的影响。
Hum Brain Mapp. 2011 Nov;32(11):1856-67. doi: 10.1002/hbm.21150. Epub 2011 Jan 18.
10
The 5-HTTLPR polymorphism is associated with altered hemodynamic responses during appetitive conditioning.5-HTTLPR 多态性与食欲条件反射过程中血流动力学反应的改变有关。
Hum Brain Mapp. 2013 Oct;34(10):2549-60. doi: 10.1002/hbm.22085. Epub 2012 Apr 16.
引用本文的文献
1
A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.一种与差异易感性相关的应激相关障碍的脆弱性和复原力神经模型。
Mol Psychiatry. 2022 Jan;27(1):514-524. doi: 10.1038/s41380-021-01047-8. Epub 2021 Mar 1.
2
Fronto-Limbic Alterations in Negatively Biased Attention in Young Adults with Subthreshold Depression.阈下抑郁的年轻成年人负性偏向注意中的额边缘改变
Front Psychol. 2017 Aug 7;8:1354. doi: 10.3389/fpsyg.2017.01354. eCollection 2017.
3
Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.调节血清素能多态性的性别差异与抑郁症及相关疾病的风险机制途径有关。
J Neurosci Res. 2017 Jan 2;95(1-2):737-762. doi: 10.1002/jnr.23877.
4
Stressful life events moderate the relationship between genes and biased attention to emotional faces in youth.压力性生活事件调节了青少年基因与对情绪面孔的偏向性注意之间的关系。
Clin Psychol Sci. 2016 May;4(3):386-400. doi: 10.1177/2167702615601000. Epub 2015 Oct 30.
5
The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study.5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）及缬氨酸66蛋氨酸（Val66Met）多态性对抑郁症患者边缘系统及边缘旁系统皮质厚度和体积的影响：一项初步研究。
BMC Psychiatry. 2016 Mar 15;16:61. doi: 10.1186/s12888-016-0777-x.
6
Amygdala Volume in Offspring from Multiplex for Alcohol Dependence Families: The Moderating Influence of Childhood Environment and 5-HTTLPR Variation.酒精依赖多重家庭子代的杏仁核体积：童年环境和5-羟色胺转运体基因启动子区域多态性的调节作用
J Alcohol Drug Depend. 2013 Dec 12;Suppl 1. doi: 10.4172/2329-6488.S1-001.
7
General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.早年心理社会逆境对青少年灰质体积的一般和特定影响。
Neuroimage Clin. 2014 Jan 11;4:308-18. doi: 10.1016/j.nicl.2014.01.001. eCollection 2014.
8
Attention biases and habituation of attention biases are associated with 5-HTTLPR and COMTval158met.注意偏向及注意偏向的习惯化与5-羟色胺转运体基因启动子区域多态性（5-HTTLPR）和儿茶酚-O-甲基转移酶基因缬氨酸158蛋氨酸多态性（COMTval158met）相关。
Cogn Affect Behav Neurosci. 2014 Mar;14(1):354-63. doi: 10.3758/s13415-013-0200-8.
9
The serotonergic system in mood disorders and suicidal behaviour.情绪障碍和自杀行为中的 5-羟色胺能系统。
Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20120537. doi: 10.1098/rstb.2012.0537. Print 2013.
10
The effects of mindfulness-based cognitive therapy on affective memory recall dynamics in depression: a mechanistic model of rumination.正念认知疗法对抑郁症中情绪记忆回忆动态的影响：反刍的机制模型。
Front Hum Neurosci. 2012 Sep 19;6:257. doi: 10.3389/fnhum.2012.00257. eCollection 2012.
本文引用的文献
1
The NimStim set of facial expressions: judgments from untrained research participants.NimStim面部表情集：来自未经训练的研究参与者的判断
Psychiatry Res. 2009 Aug 15;168(3):242-9. doi: 10.1016/j.psychres.2008.05.006. Epub 2009 Jun 28.
2
Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism.额叶-边缘白质通路与血清素转运体基因启动子区域（5-HTTLPR）多态性的关联。
J Neurosci. 2009 May 13;29(19):6229-33. doi: 10.1523/JNEUROSCI.0896-09.2009.
3
Common and distinct brain networks underlying explicit emotional evaluation: a meta-analytic study.明确情绪评估的常见和独特大脑网络：一项元分析研究。
Soc Cogn Affect Neurosci. 2012 Jun;7(5):521-34. doi: 10.1093/scan/nsp001. Epub 2009 Mar 6.
4
Regional fMRI brain activation does correlate with global brain volume.
Brain Res. 2009 Mar 9;1259:17-25. doi: 10.1016/j.brainres.2008.12.044. Epub 2008 Dec 25.
5
Regional white matter volume differences in nondemented aging and Alzheimer's disease.非痴呆性衰老和阿尔茨海默病中区域白质体积差异
Neuroimage. 2009 Feb 15;44(4):1247-58. doi: 10.1016/j.neuroimage.2008.10.030. Epub 2008 Nov 5.
6
Prefrontal-subcortical pathways mediating successful emotion regulation.介导成功情绪调节的前额叶-皮质下通路。
Neuron. 2008 Sep 25;59(6):1037-50. doi: 10.1016/j.neuron.2008.09.006.
7
Fear, faces, and the human amygdala.恐惧、面孔与人类杏仁核。
Curr Opin Neurobiol. 2008 Apr;18(2):166-72. doi: 10.1016/j.conb.2008.06.006. Epub 2008 Aug 12.
8
Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies.情绪中的功能分组与皮质-皮质下相互作用：神经影像学研究的荟萃分析
Neuroimage. 2008 Aug 15;42(2):998-1031. doi: 10.1016/j.neuroimage.2008.03.059. Epub 2008 Apr 11.
9
Effects of threat cues on attentional shifting, disengagement and response slowing in anxious individuals.威胁线索对焦虑个体注意力转移、脱离及反应迟缓的影响。
Behav Res Ther. 2008 May;46(5):656-67. doi: 10.1016/j.brat.2008.02.011. Epub 2008 Mar 4.
10
HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.下丘脑-垂体-肾上腺轴反应性：5-羟色胺转运体基因启动子区多态性、应激与抑郁之间关联的潜在机制
Biol Psychiatry. 2008 May 1;63(9):847-51. doi: 10.1016/j.biopsych.2007.10.008. Epub 2007 Nov 19.
Zotero 插件