Department of Psychology, University of Helsinki, Finland.
Genes Brain Behav. 2010 Apr;9(3):318-24. doi: 10.1111/j.1601-183X.2009.00561.x. Epub 2009 Dec 17.
This study was conducted with a purpose to examine whether the T102C polymorphism of the serotonin receptor 2A (HTR2A) gene moderates the association between parental education and children's school achievement across nine compulsory school years. The study was carried out in a population-based sample of Finnish students (aged 9, 12 and 15 years, n = 982). It was found that the HTR2A gene was not related to the school achievement at any school level, but moderated the association between maternal education and the children's grade point averages. The T/T genotype carriers benefited most from high-maternal education, and suffered from a low one more than the carriers of the other variants of the HTR2A gene. The present finding may at least partly answer the important question why academic outcomes of environmental interventions vary even at the same intelligence levels of the students.
本研究旨在检验 5-羟色胺受体 2A（HTR2A）基因 T102C 多态性是否调节了父母教育与儿童在九个义务教育年中学校成绩之间的关系。该研究在芬兰学生的基于人群的样本中进行（年龄为 9、12 和 15 岁，n = 982）。结果发现，HTR2A 基因与任何学校水平的学业成绩均无关，但调节了母亲教育与儿童平均绩点之间的关系。T/T 基因型携带者从高母亲教育中获益最多，而与 HTR2A 基因的其他变体携带者相比，他们从低母亲教育中受到的影响更大。这一发现至少可以部分回答为什么即使在学生的相同智力水平下，环境干预的学术成果也会有所不同这一重要问题。
