Jokela Markus, Lehtimäki Terho, Keltikangas-Järvinen Liisa
Department of Psychology, University of Helsinki, PO Box 9, Helsinki 00014, Finland.
Behav Genet. 2007 Jul;37(4):567-74. doi: 10.1007/s10519-007-9157-0. Epub 2007 May 9.
We examined whether the T102C polymorphism of the serotonin receptor 2A gene (HTR2A) moderated the influence of childhood or adolescence parental socioeconomic status (SES) on adulthood temperament trait harm avoidance (HA) in a population-based sample of 1246 healthy Finnish men and women, who were 24-39 years of age in the last follow-up phase. High parental SES predicted low adulthood HA. In addition, the C allele of the T102C polymorphism was associated with high HA in one of the two test settings, and with the mean of the two measurements. Most importantly, we found that the T102C polymorphism moderated the influence of parental SES, such that high parental SES predicted low adulthood HA in subjects with the T/T or T/C genotypes, while this was not true for those carrying the C/C genotype. The role of the T102C polymorphism was most pronounced among those with high parental SES. We conclude that the T102C polymorphism of the HTR2A gene may be involved in the development of temperament by moderating the influence of environmental conditions.
我们在一个基于人群的样本中，对1246名健康的芬兰男性和女性进行了研究，这些人在最后随访阶段的年龄为24 - 39岁，以检验血清素受体2A基因（HTR2A）的T102C多态性是否调节童年或青少年时期父母社会经济地位（SES）对成年期气质特质回避伤害（HA）的影响。高父母SES预示着低成年期HA。此外，在两种测试环境之一中，T102C多态性的C等位基因与高HA相关，并且与两次测量的平均值相关。最重要的是，我们发现T102C多态性调节了父母SES的影响, 即对于T/T或T/C基因型的受试者，高父母SES预示着低成年期HA，而对于携带C/C基因型的受试者则并非如此。T102C多态性的作用在高父母SES的人群中最为明显。我们得出结论，HTR2A基因的T102C多态性可能通过调节环境条件的影响而参与气质的发展。
