Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro M L
Department of Neurological Sciences, Neurosurgical Clinic, Federico II University, Naples, Italy.
Clin Neuropathol. 2010 Jan-Feb;29(1):9-13. doi: 10.5414/npp29009.
The aim of this report is to describe 3 cases of salivary gland tumors with intracranial extension associated to an extracerebral mass lesion, and to discuss the frequence, pathology and treatment of these very rare localizations.
The 3 patients were 1 woman and 2 men, aged 44, 53 and 74 years, respectively. The primary tumors were an adenocarcinoma and a malignant oncocytoma of the parotid gland and an adenoid cystic carcinoma of the submandibular gland. The location of the intradural extra-axial tumor was the middle fossa and temporal region in 2 cases and the cerebellopontine angle in 1. Surgical treatment consisted in the seemingly complete removal of 2 tumors with middle fossa localization and partial removal of the cerebellopontine angle lesion. Radiotherapy was administered in all 3 cases and chemotherapy in 2.
1 patient is alive and free of recurrence 32 months after removal of the intracranial tumor; 2 other patients died 28 months and 12 months postoperatively.
The intracranial extension of salivary gland tumors is a very rare event. An aggressive surgical resection followed by radiotherapy is justified in cases with significant intracranial mass lesions and scarce bone and dural involvement.
本报告旨在描述3例涎腺肿瘤伴颅内扩展并与脑外肿块病变相关的病例，并探讨这些极为罕见的定位情况的发生率、病理学及治疗方法。
3例患者分别为1名女性和2名男性，年龄分别为44岁、53岁和74岁。原发性肿瘤分别为腮腺腺癌、恶性嗜酸性细胞瘤以及下颌下腺腺样囊性癌。硬膜内轴外肿瘤的位置，2例位于中颅窝和颞区，1例位于桥小脑角。手术治疗包括看似完整切除2例位于中颅窝的肿瘤以及部分切除桥小脑角病变。3例均接受了放疗，2例接受了化疗。
1例患者在切除颅内肿瘤32个月后存活且无复发；另外2例患者分别在术后28个月和12个月死亡。
涎腺肿瘤的颅内扩展是非常罕见的情况。对于颅内肿块病变明显且骨和硬膜受累较少的病例，积极的手术切除后进行放疗是合理的。
