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妊娠期糖尿病产后葡萄糖检测的流行率和时间以及持续的葡萄糖失调。

Prevalence and timing of postpartum glucose testing and sustained glucose dysregulation after gestational diabetes mellitus.

机构信息

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.

出版信息

Diabetes Care. 2010 Mar;33(3):569-76. doi: 10.2337/dc09-2095. Epub 2009 Dec 29.

DOI:10.2337/dc09-2095
PMID:20040657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2827509/
Abstract

OBJECTIVE To estimate the prevalence of postpartum glucose testing within 6 months of pregnancies complicated by gestational diabetes mellitus (GDM), assess factors associated with testing and timing of testing after delivery, and report the test results among tested women. RESEARCH DESIGN AND METHODS This was a retrospective study of 11,825 women who were identified as having GDM using the 100-g oral glucose tolerance test (OGTT) from 1999 to 2006. Postpartum testing (75-g 2-h OGTT or fasting plasma glucose [FPG]) within 6 months of delivery and test results from laboratory databases are reported. Postpartum test results are categorized as normal, impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT), and provisionally diabetic. RESULTS About half (n = 5,939) the women were tested with either a FPG or 75-g OGTT from 7 days to 6 months postpartum. Of these women, 46% were tested during the 6- to 12-week postpartum period. Odds of testing were independently associated with age, race/ethnicity, household income, education, foreign-born status, parity, mode of delivery, having a postpartum visit, having GDM coded at discharge, and pharmacotherapy for GDM. Of the 5,857 women with test results, 16.3% (n = 956) had IFG/IGT and 1.1% (n = 66) had provisional diabetes. After adjustment for demographic and clinical factors, abnormal postpartum test results was associated with having required insulin, glyburide, or metformin during pregnancy and with longer period from delivery to postpartum testing. CONCLUSIONS After a pregnancy complicated by GDM, automated orders for postpartum testing with notification to physicians and electronically generated telephone and e-mail reminder messages to patients may improve the rates of postpartum testing for persistence of glucose intolerance.

摘要

目的

评估患有妊娠期糖尿病(GDM)孕妇产后 6 个月内进行葡萄糖检测的流行率,评估与检测相关的因素和产后检测的时间,并报告已检测女性的检测结果。

研究设计和方法

本研究回顾性分析了 1999 年至 2006 年期间通过 100g 口服葡萄糖耐量试验(OGTT)诊断为 GDM 的 11825 名女性。报告了产后 6 个月内(75g 2 小时 OGTT 或空腹血糖[FPG])的检测情况以及实验室数据库中的检测结果。产后检测结果分为正常、空腹血糖受损(IFG)和/或糖耐量受损(IGT)以及暂定糖尿病。

结果

大约一半(n=5939)的女性在产后 7 天至 6 个月期间进行了 FPG 或 75g OGTT 检测。这些女性中有 46%在产后 6-12 周期间进行了检测。检测的可能性与年龄、种族/民族、家庭收入、教育程度、外国出生、产次、分娩方式、产后就诊、出院时 GDM 编码以及 GDM 的药物治疗有关。在有检测结果的 5857 名女性中,16.3%(n=956)有 IFG/IGT,1.1%(n=66)有暂定糖尿病。在调整了人口统计学和临床因素后,异常的产后检测结果与怀孕期间需要胰岛素、格列美脲或二甲双胍以及从分娩到产后检测的时间较长有关。

结论

对于患有 GDM 的孕妇,通过自动下达产后检测医嘱,并向医生发出通知,以及通过电子生成电话和电子邮件提醒患者,可以提高产后葡萄糖耐量持续异常的检测率。

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ACOG Committee Opinion No. 435: postpartum screening for abnormal glucose tolerance in women who had gestational diabetes mellitus.美国妇产科医师学会第435号委员会意见:对患有妊娠期糖尿病的女性进行产后糖耐量异常筛查。
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