Indian J Pharmacol. 2008 Jun;40(3):107-10. doi: 10.4103/0253-7613.42302.
To assess the safety and efficacy of TCE in human immuno-deficiency virus positive patients.
Efficacy of Tinospora cordifolia extract (TCE) in HIV positive patients was assessed in randomized double blind placebo controlled trial. 68 HIV positive participants were randomly assigned to two groups to receive either TCE or placebo for six months. After clinical examination TLC, DLC, ESR, platelet count, hemoglobin and CD4 count were done. The hematological investigations were repeated at bimonthly intervals and CD4 count was repeated at the end of the study. Patients were clinically reviewed at monthly intervals for compliance, refill and ADR monitoring. The drugs were decoded at the end of the trial.
TCE treatment caused significant reduction in eosinophil count and hemoglobin percentage. 60% patients receiving TCE and 20% on placebo reported decrease in the incidence of various symptoms associated with disease. Some of the common complaints reported by patients on TCE were anorexia, nausea, vomiting and weakness.
Tinospora cordifolia extract, a plant derived immunostimulant, significantly affected the symptoms of HIV. This was validated by clinical evaluation. However not all of the objective parameters studied by us, back this up. Tinospora cordifolia could be used as an adjunct to HIV/AIDS management.
评估三叶鬼针草提取物（TCE）在人类免疫缺陷病毒阳性患者中的安全性和疗效。
采用随机双盲安慰剂对照试验评估三叶鬼针草提取物（TCE）对 HIV 阳性患者的疗效。将 68 名 HIV 阳性参与者随机分为两组，分别接受 TCE 或安慰剂治疗 6 个月。临床检查后，进行 TLC、DLC、ESR、血小板计数、血红蛋白和 CD4 计数。每隔两个月重复进行一次血液学检查，研究结束时重复进行 CD4 计数。每月对患者进行临床评估，以监测依从性、补充药物和不良反应。试验结束时对药物进行解码。
TCE 治疗导致嗜酸性粒细胞计数和血红蛋白百分比显著降低。接受 TCE 治疗的 60%患者和安慰剂组的 20%患者报告称，与疾病相关的各种症状的发生率降低。一些患者在服用 TCE 后报告的常见不良反应包括食欲不振、恶心、呕吐和乏力。
从植物中提取的免疫刺激剂三叶鬼针草提取物显著影响 HIV 患者的症状。这通过临床评估得到了验证。然而，我们研究的并非所有客观参数都支持这一结论。三叶鬼针草可作为 HIV/AIDS 管理的辅助药物。
