Sharma Sanjeev, Godatwar Pawankumar, Pareek Manohar, Meena Hml, Sharma Anand, Tamoli Sanjay
Ayurvedic Surgery, National Institute of Ayurveda, Jaipur, IND.
Ayurvedic Pathology, National Institute of Ayurveda, Jaipur, IND.
Cureus. 2024 Apr 23;16(4):e58807. doi: 10.7759/cureus.58807. eCollection 2024 Apr.
Background and objectives Guduchi () is a well-known Ayurvedic herb used as a preventive and curative remedy for various infections and immunity-related conditions. This study aimed to evaluate Guduchi Ghana Vati as a preventive remedy for COVID-19 and non-COVID-19 infections in a healthy population. Materials and methods An open-labeled, multi-centric, randomized, comparative, interventional, prospective community-based clinical study was conducted on healthy individuals at the community level in five different districts of Rajasthan by the National Institute of Ayurveda (NIA), Jaipur, India. Participants were divided into two groups. One group received Guduchi Ghana Vati as an intervention for 45 days, and the control group did not receive any intervention. Incidences of COVID-19 infection, non-COVID-19 infections, their severity, and hospitalization requirements were assessed. Safety was evaluated through monitoring of adverse reactions. Results Among the 10,022 participants who completed the study, the incidence of COVID-19 infection was found to be lower in those taking Guduchi Ghana Vati compared to the control group; however, the difference was statistically non-significant. The severity of COVID-19 based on the WHO ordinal scale was found to be significantly lower in the Guduchi Ghana Vati group compared to the control group. The number of episodes and severity of non-COVID-19 illness were also significantly lower in participants taking Guduchi Ghana Vati compared to the control group. No major adverse drug reactions were observed. Conclusion Guduchi Ghana Vati has the potential to act as a safe and effective remedy for the prevention of infection and immunity-related conditions, including COVID-19.
背景与目的 古杜奇（）是一种著名的阿育吠陀草药，用作各种感染和免疫相关病症的预防和治疗药物。本研究旨在评估古杜奇加纳丸在健康人群中作为预防新冠病毒病和非新冠病毒病感染的药物。材料与方法 印度斋浦尔的国家阿育吠陀研究所（NIA）在拉贾斯坦邦五个不同地区的社区层面，对健康个体开展了一项开放标签、多中心、随机、对照、干预性、前瞻性社区临床研究。参与者被分为两组。一组接受古杜奇加纳丸干预45天，对照组不接受任何干预。评估新冠病毒病感染、非新冠病毒病感染的发生率、严重程度以及住院需求。通过监测不良反应评估安全性。结果 在完成研究的10,022名参与者中，服用古杜奇加纳丸的人群中新冠病毒病感染发生率低于对照组；然而，差异无统计学意义。根据世界卫生组织序贯量表，古杜奇加纳丸组的新冠病毒病严重程度显著低于对照组。服用古杜奇加纳丸的参与者中非新冠病毒病疾病的发作次数和严重程度也显著低于对照组。未观察到重大药物不良反应。结论 古杜奇加纳丸有可能作为预防包括新冠病毒病在内的感染和免疫相关病症的安全有效药物。
