辣木叶的乙醇提取物的体内抗疟活性。
In vivo antimalarial activity of ethanolic leaf extract of Stachytarpheta cayennensis.
出版信息
Indian J Pharmacol. 2008 Jun;40(3):111-3. doi: 10.4103/0253-7613.42303.
OBJECTIVE
To evaluate the in vivo antiplasmodial activity of the ethanol leaf extract of Stachytarpheta cayennensis in the treatment of various ailment in Niger Delta region of Nigeria, in Plasmodium berghei infected mice.
MATERIALS AND METHODS
The ethanolic leaf extract of Stachytarpheta cayennensis (90-270 mg/kg/day) was screened for blood schizonticidal activity against chloroquine sensitive Plasmodium berghei berghei in mice. The schizonticidal effect during early and established infections was investigated.
RESULT
Stachytarpheta cayennensis (90-270 mg/kg/day) exhibited significant (P< 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day.
CONCLUSION
The leaf extract possesses significant (P< 0.05) antiplasmodial activity which confirms it's use in folkloric medicine in the treatment of malaria.
目的
评估在尼日利亚尼日尔三角洲地区，用治疗各种疾病的乙醇叶提取物治疗间日疟原虫感染小鼠的体内抗疟原虫活性。
材料与方法
用氯喹敏感的伯氏疟原虫感染小鼠，对 Stachytarpheta cayennensis 的乙醇叶提取物（90-270mg/kg/天）进行血裂殖体杀灭活性筛选。研究早期和已建立的感染中的裂殖体杀灭作用。
结果
Stachytarpheta cayennensis（90-270mg/kg/天）在 4 天的早期感染试验和已建立的感染中均表现出显著的（P<0.05）血裂殖体杀灭活性，平均存活时间与标准药物氯喹（5mg/kg/天）相当。
结论
该叶提取物具有显著的（P<0.05）抗疟原虫活性，证实了它在民间医学中用于治疗疟疾的用途。
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