Department of Chemistry, Faculty of Science, University of Uyo, Uyo, Nigeria.
Indian J Pharmacol. 2009 Dec;41(6):258-61. doi: 10.4103/0253-7613.59924.
To evaluate the in vivo antimalarial activities of ethanolic leaf and stembark extracts of Anthocleista djalonensis used traditionally as malarial remedy in Southern Nigeria in mice infected with Plasmodium berghei berghei.
The ethanolic extracts of the A. djalonensis leaf (1000 - 3000 mg/kg/day) and stembark (220 - 660 mg/kg/day) were screened for blood schizonticidal activity against chloroquine-sensitive P. berghei in mice. The schizonticidal effect during early and established infections was investigated.
The A. djalonensis leaf extract (1000 - 3000 mg/kg/day) exhibited a significant antiplasmodial activity both in the 4-day early infection test and in the established infection with a considerable mean survival time, which was incomparable to that of the standard drug, chloroquine (5 mg/kg/day). The stembark extract (220 - 660 mg/kg/day) also demonstrated a promising blood schizontocidal activity in early and established infections.
These plant extracts possess considerable antiplasmodial activities, which justify their use in ethnomedicine and can be exploited in malaria therapy.
评估传统上用于治疗尼日利亚南部疟疾的 Anthocleista djalonensis 叶和茎皮乙醇提取物在感染 Plasmodium berghei berghei 的小鼠体内的抗疟活性。
用乙醇对 A. djalonensis 叶（1000-3000 mg/kg/天）和茎皮（220-660 mg/kg/天）提取物进行筛选，以检测其对氯喹敏感的 P. berghei 的血裂殖体活性。研究了早期和已建立的感染期间的裂殖体杀灭作用。
A. djalonensis 叶提取物（1000-3000 mg/kg/天）在 4 天的早期感染试验和已建立的感染中均表现出显著的抗疟活性，其平均存活时间与标准药物氯喹（5 mg/kg/天）相当。茎皮提取物（220-660 mg/kg/天）在早期和已建立的感染中也表现出有希望的血裂殖体杀灭活性。
这些植物提取物具有相当的抗疟活性，这证明了它们在民族医学中的应用，并可用于疟疾治疗。
