Notch 信号通路在发育和肿瘤侵袭过程中的上皮-间充质转化（EMT）中的作用。
The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness.
机构信息
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
出版信息
Curr Drug Targets. 2010 Jun;11(6):745-51. doi: 10.2174/138945010791170860.
Abstract
The Notch signaling pathway maintains a balance between cell proliferation and apoptosis, and thus it is believed that Notch signaling pathways may play an important role in the development and progression of several malignancies. However, the functions of Notch signaling in EMT are largely unknown. This mini review describes the role of Notch signaling pathway in EMT, and cataloging how its deregulation is involved in EMT and tumor aggressiveness. Further attempts have been made to summarize the role of several chemopreventive agents that could be useful for targeted inactivation of Notch signaling, and thus it may cause reversal of EMT, which could become a novel approach for cancer prevention and treatment.
摘要
Notch 信号通路在细胞增殖和凋亡之间维持平衡，因此人们认为 Notch 信号通路可能在多种恶性肿瘤的发生和发展中发挥重要作用。然而，Notch 信号在 EMT 中的功能在很大程度上是未知的。这篇迷你综述描述了 Notch 信号通路在 EMT 中的作用，并列出了其失调如何参与 EMT 和肿瘤侵袭性。进一步的尝试已经被用来总结几种化学预防剂的作用，这些化学预防剂可能对 Notch 信号的靶向失活有用，从而可能导致 EMT 的逆转，这可能成为癌症预防和治疗的新方法。
相似文献
1
The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness.Notch 信号通路在发育和肿瘤侵袭过程中的上皮-间充质转化（EMT）中的作用。
Curr Drug Targets. 2010 Jun;11(6):745-51. doi: 10.2174/138945010791170860.
2
Regulation of EMT by Notch signaling pathway in tumor progression.Notch 信号通路在肿瘤进展中的 EMT 调控。
Curr Cancer Drug Targets. 2013 Nov;13(9):957-62. doi: 10.2174/15680096113136660101.
3
Exploitation of the Notch signaling pathway as a novel target for cancer therapy.将Notch信号通路作为癌症治疗新靶点的研究
Anticancer Res. 2008 Nov-Dec;28(6A):3621-30.
4
Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells.致命串扰：Notch 信号在 EMT 和癌症干细胞中的交汇
Cancer Lett. 2013 Nov 28;341(1):41-5. doi: 10.1016/j.canlet.2013.08.027. Epub 2013 Aug 21.
5
Emerging role of Notch in stem cells and cancer.Notch信号通路在干细胞和癌症中的新作用
Cancer Lett. 2009 Jun 28;279(1):8-12. doi: 10.1016/j.canlet.2008.09.030. Epub 2008 Nov 20.
6
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.吉西他滨耐药胰腺癌细胞上皮-间质转化表型的获得与Notch信号通路的激活有关。
Cancer Res. 2009 Mar 15;69(6):2400-7. doi: 10.1158/0008-5472.CAN-08-4312. Epub 2009 Mar 10.
7
Notch signaling mediates hypoxia-induced tumor cell migration and invasion.Notch信号传导介导缺氧诱导的肿瘤细胞迁移和侵袭。
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6392-7. doi: 10.1073/pnas.0802047105. Epub 2008 Apr 21.
8
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression.在胚胎发育和癌症进展过程中引导上皮-间质转化的信号网络。
Cancer Sci. 2007 Oct;98(10):1512-20. doi: 10.1111/j.1349-7006.2007.00550.x. Epub 2007 Jul 23.
9
Notch signaling proteins: legitimate targets for cancer therapy.Notch 信号蛋白：癌症治疗的合法靶点。
Curr Protein Pept Sci. 2010 Sep;11(6):398-408. doi: 10.2174/138920310791824039.
10
Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy.癌症转移中的 Notch 信号通路网络：癌症治疗的新靶点。
Med Oncol. 2017 Sep 16;34(10):180. doi: 10.1007/s12032-017-1039-6.
引用本文的文献
1
Epithelial-Mesenchymal Transition in Osteosarcoma as a Key Driver of Pulmonary Metastasis.骨肉瘤中的上皮-间质转化作为肺转移的关键驱动因素
Cancers (Basel). 2025 Sep 6;17(17):2922. doi: 10.3390/cancers17172922.
2
ALDH1A1 promotes colorectal cancer metastasis through activating the notch signaling pathway.醛脱氢酶1A1通过激活Notch信号通路促进结直肠癌转移。
Med Oncol. 2025 Aug 4;42(9):403. doi: 10.1007/s12032-025-02958-0.
3
Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC.整合空间组学揭示了美国黑人与白人三阴性乳腺癌患者中不同的促肿瘤多细胞生态位和免疫抑制机制。
Nat Commun. 2025 Jul 17;16(1):6584. doi: 10.1038/s41467-025-61034-3.
4
Recent advances in novel targeting mechanisms for colorectal cancer.结直肠癌新型靶向机制的最新进展
Clin Transl Oncol. 2025 Jul 11. doi: 10.1007/s12094-025-03990-2.
5
Decoding the NRF2-NOTCH Crosstalk in Lung Cancer-An Update.肺癌中NRF2-NOTCH信号通路交互作用的解析——最新进展
Antioxidants (Basel). 2025 May 29;14(6):657. doi: 10.3390/antiox14060657.
6
Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer.简而言之：前列腺癌中的信号通路——从发病机制到治疗意义
Ann Med. 2025 Dec;57(1):2474175. doi: 10.1080/07853890.2025.2474175. Epub 2025 May 15.
7
Evaluation of Notch1 and CD10 Expressions in Colorectal Carcinoma and Their Relationship with Prognosis.Notch1和CD10在结直肠癌中的表达及其与预后的关系评估
Iran J Pathol. 2025;20(1):68-75. doi: 10.30699/ijp.2024.2029781.3304. Epub 2025 Jan 10.
8
ADAM10 is a key player in the diagnosis, prognosis and metastasis of non-small cell lung cancer (NSCLC).ADAM10在非小细胞肺癌（NSCLC）的诊断、预后和转移中起着关键作用。
J Cancer. 2025 Feb 11;16(5):1736-1746. doi: 10.7150/jca.107236. eCollection 2025.
9
Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers.利用膳食植物化合物和重新利用的药物组合靶向上皮-间质转化信号通路以克服各种癌症中的耐药性。
Heliyon. 2025 Jan 23;11(3):e41964. doi: 10.1016/j.heliyon.2025.e41964. eCollection 2025 Feb 15.
10
Despicable role of epithelial-mesenchymal transition in breast cancer metastasis: Exhibiting restorative regimens.上皮-间质转化在乳腺癌转移中的可鄙作用：展示恢复性方案。
Cancer Pathog Ther. 2024 Jan 12;3(1):30-47. doi: 10.1016/j.cpt.2024.01.001. eCollection 2025 Jan.
本文引用的文献
1
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.上皮-间质转化促进胰腺癌的耐药性。
Cancer Res. 2009 Jul 15;69(14):5820-8. doi: 10.1158/0008-5472.CAN-08-2819. Epub 2009 Jul 7.
2
miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.miR-200 调节 PDGF-D 介导的前列腺癌细胞上皮-间充质转化、黏附和侵袭。
Stem Cells. 2009 Aug;27(8):1712-21. doi: 10.1002/stem.101.
3
The canonical Notch signaling pathway: unfolding the activation mechanism.经典Notch信号通路：揭示激活机制
Cell. 2009 Apr 17;137(2):216-33. doi: 10.1016/j.cell.2009.03.045.
4
Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe.上皮-间质转化：癌症研究者亦敌亦友的概念。
Am J Pathol. 2009 May;174(5):1588-93. doi: 10.2353/ajpath.2009.080545. Epub 2009 Mar 26.
5
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.吉西他滨耐药胰腺癌细胞上皮-间质转化表型的获得与Notch信号通路的激活有关。
Cancer Res. 2009 Mar 15;69(6):2400-7. doi: 10.1158/0008-5472.CAN-08-4312. Epub 2009 Mar 10.
6
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression.Let-7和miR-200微小RNA：多能性和癌症进展的守护者。
Cell Cycle. 2009 Mar 15;8(6):843-52. doi: 10.4161/cc.8.6.7907. Epub 2009 Mar 22.
7
Exploitation of the Notch signaling pathway as a novel target for cancer therapy.将Notch信号通路作为癌症治疗新靶点的研究
Anticancer Res. 2008 Nov-Dec;28(6A):3621-30.
8
PDGF-D signaling: a novel target in cancer therapy.血小板衍生生长因子-D信号传导：癌症治疗中的一个新靶点。
Curr Drug Targets. 2009 Jan;10(1):38-41. doi: 10.2174/138945009787122914.
9
Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer.乳腺癌中刺猬信号通路、Wnt信号通路和Notch信号通路的失调。
Histol Histopathol. 2009 Mar;24(3):385-98. doi: 10.14670/HH-24.385.
10
Transcriptional regulation of cell polarity in EMT and cancer.上皮-间质转化和癌症中细胞极性的转录调控
Oncogene. 2008 Nov 24;27(55):6958-69. doi: 10.1038/onc.2008.346.
Zotero 插件