Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Curr Drug Targets. 2010 Jun;11(6):745-51. doi: 10.2174/138945010791170860.
The Notch signaling pathway maintains a balance between cell proliferation and apoptosis, and thus it is believed that Notch signaling pathways may play an important role in the development and progression of several malignancies. However, the functions of Notch signaling in EMT are largely unknown. This mini review describes the role of Notch signaling pathway in EMT, and cataloging how its deregulation is involved in EMT and tumor aggressiveness. Further attempts have been made to summarize the role of several chemopreventive agents that could be useful for targeted inactivation of Notch signaling, and thus it may cause reversal of EMT, which could become a novel approach for cancer prevention and treatment.
Notch 信号通路在细胞增殖和凋亡之间维持平衡，因此人们认为 Notch 信号通路可能在多种恶性肿瘤的发生和发展中发挥重要作用。然而，Notch 信号在 EMT 中的功能在很大程度上是未知的。这篇迷你综述描述了 Notch 信号通路在 EMT 中的作用，并列出了其失调如何参与 EMT 和肿瘤侵袭性。进一步的尝试已经被用来总结几种化学预防剂的作用，这些化学预防剂可能对 Notch 信号的靶向失活有用，从而可能导致 EMT 的逆转，这可能成为癌症预防和治疗的新方法。
