Notch信号通路在干细胞和癌症中的新作用
Emerging role of Notch in stem cells and cancer.
作者信息
Wang Zhiwei, Li Yiwei, Banerjee Sanjeev, Sarkar Fazlul H
机构信息
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 E Canfield, Detroit, MI 48201, United States.
出版信息
Cancer Lett. 2009 Jun 28;279(1):8-12. doi: 10.1016/j.canlet.2008.09.030. Epub 2008 Nov 20.
Abstract
The Notch signaling pathway is known to be responsible for maintaining a balance between cell proliferation and death and, as such, plays important roles in the formation of many types of human tumors. Recently, Notch signaling pathway has been shown to control stem cell self-renewal and multi-potency. As many cancers are thought to be developed from a number of cancer stem-like cells, which are also known to be linked with the acquisition of epithelial-mesenchymal transition (EMT); and thus suggesting an expanding role of Notch signaling in human tumor progression.
摘要
已知Notch信号通路负责维持细胞增殖与死亡之间的平衡，因此在多种人类肿瘤的形成中发挥重要作用。最近，Notch信号通路已被证明可控制干细胞的自我更新和多能性。由于许多癌症被认为是由一些癌症干细胞样细胞发展而来，这些细胞也被认为与上皮-间质转化（EMT）的发生有关；因此提示Notch信号在人类肿瘤进展中的作用不断扩大。
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