Wilson Kathryn M, Mucci Lorelei A, Drake Bettina F, Preston Mark A, Stampfer Meir J, Giovannucci Edward, Kibel Adam S
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Channing Division of Network Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, Massachusetts.
Cancer Prev Res (Phila). 2016 Dec;9(12):933-941. doi: 10.1158/1940-6207.CAPR-16-0070. Epub 2016 Sep 20.
Little information exists on diet and prostate cancer progression. We examined the association between intakes of total red meat, processed and unprocessed red meat, poultry, fish, and eggs and prostate cancer recurrence. We conducted a prospective study of 971 men treated with radical prostatectomy for prostate cancer between 2003 and 2010. Men completed a food frequency questionnaire at diagnosis. We used logistic regression to study the association between diet and high-grade or advanced-stage disease. We used Cox models to study the risk of progression [N = 94 events, mainly prostate-specific antigen (PSA) recurrence]. Total red meat intake was marginally associated with risk of high-grade disease [Gleason ≥ 4+3; adjusted OR top vs. bottom quartile: 1.66; 95% confidence interval (CI), 0.93-2.97; P = 0.05], as was very high intake of eggs (OR top decile vs. bottom quartile: 1.98; 95% CI, 1.08-3.63, P = 0.08). Well-done red meat was associated with advanced disease (≥pT3; OR top vs. bottom quartile: 1.74, 95% CI, 1.05-2.90; P = 0.01). Intakes of red meat, fish, and eggs were not associated with progression. Very high poultry intake was inversely associated with progression (HR top decile vs. bottom quartile: 0.19; 95% CI, 0.06-0.63; P = 0.02). Substituting 30 g/d of poultry or fish for total or unprocessed red meat was associated with significantly lower risk of recurrence. Lower intakes of red meat and well-done red meat and higher intakes of poultry and fish are associated with lower risk of high grade and advanced prostate cancer and reduced recurrence risk, independent of stage and grade. Cancer Prev Res; 9(12); 933-41. ©2016 AACR.
关于饮食与前列腺癌进展的信息很少。我们研究了总红肉、加工和未加工红肉、家禽、鱼类和蛋类的摄入量与前列腺癌复发之间的关联。我们对2003年至2010年间接受前列腺癌根治术的971名男性进行了一项前瞻性研究。男性在诊断时完成了一份食物频率问卷。我们使用逻辑回归研究饮食与高级别或晚期疾病之间的关联。我们使用Cox模型研究进展风险[94例事件，主要是前列腺特异性抗原（PSA）复发]。总红肉摄入量与高级别疾病风险略有关联[Gleason≥4+3；调整后的四分位数最高与最低组的OR：1.66；95%置信区间（CI），0.93 - 2.97；P = 0.05]，鸡蛋摄入量非常高时也是如此（十分位数最高与最低组的OR：1.98；95%CI，1.08 - 3.63，P = 0.08）。熟透的红肉与晚期疾病相关（≥pT3；四分位数最高与最低组的OR：1.74，95%CI，1.05 - 2.90；P = 0.01）。红肉、鱼类和蛋类的摄入量与进展无关。家禽摄入量非常高与进展呈负相关（十分位数最高与最低组的HR：0.19；95%CI，0.06 - 0.63；P = 0.02）。用每天30克家禽或鱼类替代总红肉或未加工红肉与复发风险显著降低相关。红肉和熟透红肉摄入量较低以及家禽和鱼类摄入量较高与高级别和晚期前列腺癌风险较低以及复发风险降低相关，与分期和分级无关。《癌症预防研究》；9(12)；933 - 41。©2016美国癌症研究协会。
