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TcpC 基因编码一种 Toll/白细胞介素-1 受体结构域蛋白，研究其在大肠埃希菌尿路感染、皮肤软组织感染和共生分离株中的流行情况及相关性。

Prevalence and associations of tcpC, a gene encoding a Toll/interleukin-1 receptor domain-containing protein, among Escherichia coli urinary tract infection, skin and soft tissue infection, and commensal isolates.

机构信息

Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana 1000, Slovenia.

出版信息

J Clin Microbiol. 2010 Mar;48(3):966-8. doi: 10.1128/JCM.01227-09. Epub 2009 Dec 30.

DOI:10.1128/JCM.01227-09
PMID:20042631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2832412/
Abstract

TcpC, a new Toll/interleukin-1 receptor domain-containing protein of uropathogenic Escherichia coli involved in the suppression of innate immunity, was found in 2008. The aim of the present study was to determine the prevalence of tcpC and its association with virulence factors and phylogenetic groups among strains from a collection of 212 E. coli isolates from urinary tract and skin and soft tissue infections and 90 commensal E. coli strains.

摘要

TcpC，一种新的尿路上皮致病性大肠杆菌中的 Toll/白细胞介素-1 受体域包含蛋白，于 2008 年被发现。本研究的目的是确定 tcpC 的流行率及其与来自尿路感染和皮肤软组织感染的 212 株大肠杆菌分离株和 90 株共生大肠杆菌分离株的毒力因子和系统发育群之间的关联。

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本文引用的文献

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Virulence potential of Escherichia coli isolates from skin and soft tissue infections.从皮肤和软组织感染中分离出的大肠杆菌的毒力潜力。
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Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins.一类独特的含细菌Toll/白细胞介素-1受体结构域蛋白对Toll样受体信号传导的颠覆。
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Chloramphenicol- and tetracycline-resistant uropathogenic Escherichia coli (UPEC) exhibit reduced virulence potential.对氯霉素和四环素耐药的尿路致病性大肠杆菌（UPEC）表现出较低的致病潜力。
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Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC.关于为大肠埃希菌肠外致病分离株设立新的包容性命名的提议：肠外致病性大肠埃希菌（ExPEC）
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