ORGANOBALANCE GmbH, Berlin, Germany.
J Dent Res. 2010 Feb;89(2):175-9. doi: 10.1177/0022034509356246. Epub 2009 Dec 30.
Selective interaction of mutans streptococci with benign bacteria could present an opportunity for their removal from the mouth without disruption of other oral flora. This study was conducted to find probiotic lactobacilli that could specifically co-aggregate in vitro with mutans streptococci, but not with other plaque commensals. A search of 624 lactobacilli among a large culture library revealed 6 strains, all classifiable as L. paracasei or L. rhamnosus, which met this criterion. Such novel, specific co-aggregation, however, was not a general characteristic of these species or the genus Lactobacillus. The co-aggregation by these specific lactobacilli was characterized as heat treatment (autoclaving)- and protease-resistant, lectin-independent, not inactivated by sugar substitutes, operational over a wide pH range, unaffected by whole saliva, but calcium-dependent. It is thus seen to present a potential strategy for in vivo alteration of plaque biofilm and caries.
变形链球菌与口腔内有益菌的选择性相互作用，可能为在不破坏其他口腔菌群的情况下将其从口腔中清除提供了机会。本研究旨在寻找能与变形链球菌特异性共聚但不与其他菌斑共生菌共聚的益生菌乳杆菌。在一个大型培养文库中对 624 株乳杆菌进行搜索，发现了 6 株均归类为副干酪乳杆菌或鼠李糖乳杆菌的菌株符合这一标准。然而，这种新的、特定的共聚并不是这些种或乳杆菌属的一般特征。这些特定乳杆菌的共聚作用具有热处理（高压灭菌）和蛋白酶抗性、不依赖凝集素、不会被糖替代品失活、在较宽 pH 范围内起作用、不受全唾液影响、但依赖于钙的特点。因此，它为体内改变菌斑生物膜和龋齿提供了一种潜在的策略。
