School of Biological Sciences, the University of Hong Kong, Hong Kong, PR China.
Nutr Cancer. 2010;62(1):1-20. doi: 10.1080/01635580903191585.
Natural phenolic compounds play an important role in cancer prevention and treatment. Phenolic compounds from medicinal herbs and dietary plants include phenolic acids, flavonoids, tannins, stilbenes, curcuminoids, coumarins, lignans, quinones, and others. Various bioactivities of phenolic compounds are responsible for their chemopreventive properties (e.g., antioxidant, anticarcinogenic, or antimutagenic and anti-inflammatory effects) and also contribute to their inducing apoptosis by arresting cell cycle, regulating carcinogen metabolism and ontogenesis expression, inhibiting DNA binding and cell adhesion, migration, proliferation or differentiation, and blocking signaling pathways. This review covers the most recent literature to summarize structural categories and molecular anticancer mechanisms of phenolic compounds from medicinal herbs and dietary plants.
天然酚类化合物在癌症的预防和治疗中起着重要作用。药用植物和食用植物中的酚类化合物包括酚酸、类黄酮、单宁、芪类、姜黄素类、香豆素类、木脂素类、醌类等。酚类化合物的各种生物活性与其化学预防特性（如抗氧化、抗癌、抗突变和抗炎作用）有关，也有助于通过阻止细胞周期、调节致癌物代谢和个体发生表达、抑制 DNA 结合和细胞黏附、迁移、增殖或分化以及阻断信号通路来诱导细胞凋亡。本综述涵盖了最新的文献，总结了药用植物和食用植物中酚类化合物的结构类别和分子抗癌机制。
