慢心慢脑：年轻女性短期职业性甲苯暴露的后果：真正的机制是什么？
Slow heart-slow brain: consequence of short-term occupational exposure to toluene in a young woman: what is the real mechanism?
机构信息
Istanbul University, Institute of Cardiology, Division of Pacing and Electrophysiology, Haseki/Fatih, Istanbul, Turkey.
出版信息
Clin Cardiol. 2010 Feb;33(2):E68-71. doi: 10.1002/clc.20525.
Abstract
Herein we describe a case of acute occupational exposure to toluene in a 27-year-old female patient, presented to the emergency department of our institute. On admission she had electrocardiographic signs of profound sinus bradycardia with sinus arrhythmia and low amplitude slow wave activity recorded on her electroencephalogram (EEG). The mechanisms underlying the cerebral and cardiac effects of toluene are also discussed.
摘要
在此，我们描述了一例 27 岁女性患者急性职业性甲苯暴露的病例，该患者因该情况被收入我院急诊科。入院时，她的心电图显示窦性心动过缓伴窦性心律失常，脑电图记录到低振幅慢波活动。我们还讨论了甲苯对大脑和心脏影响的潜在机制。
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2
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Neurotoxicol Teratol. 2007 Mar-Apr;29(2):228-35. doi: 10.1016/j.ntt.2006.10.004. Epub 2006 Oct 24.
3
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4
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