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慢心慢脑:年轻女性短期职业性甲苯暴露的后果:真正的机制是什么?

Slow heart-slow brain: consequence of short-term occupational exposure to toluene in a young woman: what is the real mechanism?

机构信息

Istanbul University, Institute of Cardiology, Division of Pacing and Electrophysiology, Haseki/Fatih, Istanbul, Turkey.

出版信息

Clin Cardiol. 2010 Feb;33(2):E68-71. doi: 10.1002/clc.20525.

DOI:10.1002/clc.20525
PMID:20043333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6653352/
Abstract

Herein we describe a case of acute occupational exposure to toluene in a 27-year-old female patient, presented to the emergency department of our institute. On admission she had electrocardiographic signs of profound sinus bradycardia with sinus arrhythmia and low amplitude slow wave activity recorded on her electroencephalogram (EEG). The mechanisms underlying the cerebral and cardiac effects of toluene are also discussed.

摘要

在此,我们描述了一例 27 岁女性患者急性职业性甲苯暴露的病例,该患者因该情况被收入我院急诊科。入院时,她的心电图显示窦性心动过缓伴窦性心律失常,脑电图记录到低振幅慢波活动。我们还讨论了甲苯对大脑和心脏影响的潜在机制。

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Clin Cardiol. 2010 Feb;33(2):E68-71. doi: 10.1002/clc.20525.
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本文引用的文献

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Glue (toluene) abuse: increased QT dispersion and relation with unexplained syncope.胶水(甲苯)滥用:QT离散度增加及其与不明原因晕厥的关系。
Inhal Toxicol. 2008 Jan;20(1):37-41. doi: 10.1080/08958370701758304.
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Cardiovascular effects of oral toluene exposure in the rat monitored by radiotelemetry.通过无线电遥测技术监测大鼠口服甲苯后的心血管效应。
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Effects of the abused inhalant toluene on ethanol-sensitive potassium channels expressed in oocytes.滥用吸入剂甲苯对卵母细胞中表达的乙醇敏感性钾通道的影响。
Brain Res. 2006 May 4;1087(1):75-82. doi: 10.1016/j.brainres.2006.03.031. Epub 2006 Apr 13.
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Inhibition of cardiac sodium currents by toluene exposure.甲苯暴露对心脏钠电流的抑制作用。
Br J Pharmacol. 2003 Oct;140(4):653-60. doi: 10.1038/sj.bjp.0705481.
5
Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene.滥用溶剂甲苯对神经元烟碱型乙酰胆碱受体的抑制作用。
Br J Pharmacol. 2002 Oct;137(3):375-83. doi: 10.1038/sj.bjp.0704874.
6
Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells.甲苯抑制嗜铬细胞瘤细胞中表达的电压敏感性钙通道。
Neurochem Int. 2002 Dec;41(6):391-7. doi: 10.1016/s0197-0186(02)00048-7.
7
Respiratory sinus arrhythmia in persons with organic solvent exposure: comparisons with anxiety patients and controls.有机溶剂暴露人群的呼吸性窦性心律失常:与焦虑症患者及对照组的比较
Arch Environ Health. 2001 Mar-Apr;56(2):175-80. doi: 10.1080/00039890109604070.
8
Inhalant abuse by adolescents.青少年吸入剂滥用
J Adolesc Health. 2001 Mar;28(3):170-80. doi: 10.1016/s1054-139x(00)00159-2.
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Effects of volatile solvents on recombinant N-methyl-D-aspartate receptors expressed in Xenopus oocytes.挥发性溶剂对非洲爪蟾卵母细胞中表达的重组N-甲基-D-天冬氨酸受体的影响。
Br J Pharmacol. 2000 Dec;131(7):1303-8. doi: 10.1038/sj.bjp.0703666.
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Mol Pharmacol. 2000 Jun;57(6):1199-205.