Department of Chemistry/Biochemistry, Philipps-University Marburg, Marburg, Germany.
FEBS Lett. 2010 Feb 19;584(4):785-9. doi: 10.1016/j.febslet.2009.12.046. Epub 2009 Dec 30.
The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. The determined lasso fold opens new avenues to improve the promising biological activity of BI-32169.
从链霉菌属中分离出来的胰高血糖素受体拮抗剂 BI-32169 被描述为一种双环肽，尽管其一级结构包含 I 类和 II 类套索肽的保守元件。串联质谱和核磁共振波谱研究表明，BI-32169 是一种套索结构的肽，构成了套索肽的新 III 类。确定的套索折叠为改善 BI-32169 的有前途的生物学活性开辟了新途径。
