单链 DNA 通过单壁碳纳米管的迁移。
Translocation of single-stranded DNA through single-walled carbon nanotubes.
机构信息
Department of Chemistry, Columbia University, New York, NY 10027, USA.
出版信息
Science. 2010 Jan 1;327(5961):64-7. doi: 10.1126/science.1181799.
Abstract
We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 10(7) charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.
摘要
我们报告了一种装置的制作方法，该装置中有一根单壁碳纳米管横跨在两个流体储层之间的障碍上，从而可以直接测量离子通过该管的传输。有一部分纳米管异常高的离子电流。通过这些纳米管的电泳传输小分子单链 DNA 寡聚物时，离子电流会发生巨大的瞬时增加，并通过聚合酶链反应分析得到证实。每个电流脉冲包含约 10(7)个电荷，这是转移电荷的巨大放大。碳纳米管简化了纳米孔的构建，允许进行新型的电测量，并可能为控制 DNA 转位开辟新途径。
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