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一项比较在肩峰下撞击症患者中肩峰下注射替诺昔康或甲基强的松龙的双盲随机对照研究。

A double-blind randomised controlled study comparing subacromial injection of tenoxicam or methylprednisolone in patients with subacromial impingement.

作者信息

Karthikeyan S, Kwong H T, Upadhyay P K, Parsons N, Drew S J, Griffin D

机构信息

Warwick Medical School, Coventry, England.

出版信息

J Bone Joint Surg Br. 2010 Jan;92(1):77-82. doi: 10.1302/0301-620X.92B1.22137.

Abstract

We have carried out a prospective double-blind randomised controlled trial to compare the efficacy of a single subacromial injection of the non-steroidal anti-inflammatory drug, tenoxicam, with a single injection of methylprednisolone in patients with subacromial impingement. A total of 58 patients were randomly allocated into two groups. Group A received 40 mg of methylprednisolone and group B 20 mg of tenoxicam as a subacromial injection along with lignocaine. The Constant-Murley shoulder score was used as the primary outcome measure and the Disability of Arm, Shoulder and Hand (DASH) and the Oxford Shoulder Score (OSS) as secondary measures. Six weeks after injection the improvement in the Constant-Murley score was significantly greater in the methylprednisolone group (p = 0.003) than in the tenoxicam group. The improvement in the DASH score was greater in the steroid group and the difference was statistically significant and consistent two (p < 0.01), four (p < 0.01) and six weeks (p < 0.020) after the injection. The improvement in the OSS was consistently greater in the steroid group than in the tenoxicam group. Although the difference was statistically significant at two (p < 0.001) and four (p = 0.003) weeks after the injection, it was not at six weeks (p = 0.055). Subacromial injection of tenoxicam does not offer an equivalent outcome to subacromial injection of corticosteroid at six weeks. Corticosteroid is significantly better than tenoxicam for improving shoulder function in tendonitis of the rotator cuff after six weeks.

摘要

我们开展了一项前瞻性双盲随机对照试验,以比较在肩峰下撞击综合征患者中,单次肩峰下注射非甾体抗炎药替诺昔康与单次注射甲泼尼龙的疗效。总共58例患者被随机分为两组。A组接受40mg甲泼尼龙,B组接受20mg替诺昔康进行肩峰下注射,同时注射利多卡因。采用Constant-Murley肩关节评分作为主要结局指标,上肢、肩部和手部功能障碍评分(DASH)和牛津肩关节评分(OSS)作为次要指标。注射后六周,甲泼尼龙组的Constant-Murley评分改善程度显著大于替诺昔康组(p = 0.003)。类固醇组的DASH评分改善程度更大,且在注射后两周(p < 0.01)、四周(p < 0.01)和六周(p < 0.020)时差异具有统计学意义且一致。类固醇组的OSS改善程度始终大于替诺昔康组。尽管在注射后两周(p < 0.001)和四周(p = 0.003)时差异具有统计学意义,但在六周时差异无统计学意义(p = 0.055)。六周时,肩峰下注射替诺昔康的效果不如肩峰下注射皮质类固醇。六周后,皮质类固醇在改善肩袖肌腱炎的肩部功能方面明显优于替诺昔康。

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