Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark.
Nano Lett. 2010 Feb 10;10(2):686-94. doi: 10.1021/nl903875r.
Focal adhesion development in cells adherent to surface bound fibronectin presented as 200, 500, or 1000 nm diameter circular patches or as homogeneous controls is studied by fluorescence and scanning electron microscopy. Fundamental cellular processes such as adhesion, spreading, focal adhesion and stress fiber formation are shown to be dependent on the spatial distribution of ligands at this scale. Large area samples enable the study of whole cell populations and opens for new potential applications.
通过荧光和扫描电子显微镜研究了在直径为 200nm、500nm 或 1000nm 的圆形斑点或均一对照的表面结合纤维连接蛋白上黏附的细胞中的粘着斑的发展。研究表明，诸如粘着、铺展、粘着斑和应力纤维形成等基本细胞过程取决于该尺度上配体的空间分布。大面积样本能够研究整个细胞群体，并为新的潜在应用开辟了道路。
