Department of Psychiatry, Vanderbilt University Medical School, Nashville, TN 37212, USA.
Neuroimage. 2010 Apr 15;50(3):1188-93. doi: 10.1016/j.neuroimage.2009.12.083. Epub 2010 Jan 4.
Previous research indicates that the amygdala and hippocampus are sensitive to novelty; however, two types of novelty can be distinguished - stimuli that are ordinary, but novel in the current context, and stimuli that are unusual. Using functional magnetic resonance imaging, we examined blood oxygen dependent level (BOLD) response of the human amygdala and hippocampus to novel, commonly seen objects versus novel unusual objects. When presented with the novel common stimuli, the BOLD signal increased significantly in both the amygdala and hippocampus. However, for the novel unusual stimuli, only the amygdala showed an increased response compared to the novel common stimuli. These findings suggest that the amygdala is distinctly responsive to novel unusual stimuli, making a unique contribution to the novelty detection circuit.
先前的研究表明，杏仁核和海马体对新奇事物敏感；然而，新奇事物可以分为两种类型 - 一种是在当前环境下普通但新颖的刺激，另一种是不寻常的刺激。使用功能磁共振成像，我们研究了人类杏仁核和海马体对新颖常见物体与新颖不寻常物体的血氧依赖水平（BOLD）反应。当呈现新颖常见的刺激时，杏仁核和海马体的 BOLD 信号都显著增加。然而，对于新颖不寻常的刺激，只有杏仁核与新颖常见刺激相比表现出增强的反应。这些发现表明，杏仁核对新颖不寻常的刺激有明显的反应，对新奇检测电路做出了独特的贡献。
